总膳食多酚和特定膳食多酚摄入量与 Nutrinet-Santé 法国队列心血管疾病风险的前瞻性关联。
Prospective Association between Total and Specific Dietary Polyphenol Intakes and Cardiovascular Disease Risk in the Nutrinet-Santé French Cohort.
机构信息
Equipe de Recherche en Epidémiologie Nutritionnelle (EREN), Centre de Recherche en Epidémiologie et Statistiques, Université Paris 13, Inserm (U1153), Inra (U1125), Cnam, COMUE Sorbonne Paris Cité, F-93017 Bobigny, France.
Département de Santé Publique, Hôpital Avicenne, F-93017 Bobigny, France.
出版信息
Nutrients. 2018 Oct 29;10(11):1587. doi: 10.3390/nu10111587.
BACKGROUND
Epidemiological and experimental evidence support a protective effect of dietary polyphenols on chronic diseases, but high quality longitudinal data are needed, including details on categories of polyphenols. Our objective was to investigate the prospective association between total and individual classes and subclasses of dietary polyphenols and the risk of major cardiovascular disease in the NutriNet-Santé cohort.
METHODS
A total of 84,158 participants, who completed at least three 24 h dietary records, were included between May 2009 and June 2017. Individual polyphenols intakes were obtained by matching food consumption data from the 24 h dietary records with the Phenol-Explorer polyphenol composition database. Multivariable Cox proportional hazards models were used to characterize the associations between dietary polyphenols and the incidence of cardiovascular diseases, comparing tertile T3 vs. T1 of classes and subclasses of polyphenols.
RESULTS
Over a median of 4.9 years of follow-up, 602 major cardiovascular events were diagnosed. Intakes of anthocyanins, catechins, and flavonols were strongly inversely associated with cardiovascular disease risk (anthocyanins: Hazard Ratio (HR) = 0.98 (0.96⁻0.99, = 0.03, HR = 0.66 (0.52⁻0.83), = 0.0003; catechins: HR = 0.98 (0.96⁻0.99), = 0.02, HR = 0.74 (0.60⁻0.91), = 0.004; flavonols: HR = 0.94 (0.90⁻0.99), = 0.02, HR = 0.75 (0.61⁻0.94), = 0.006). Intakes of dihydrochalcones, proanthocyaninidins, dihydroflavonols, hydroxybenzoic acids, and stilbenes were also associated with a decrease (13%, 19%, 24%, 24%, and 27%, respectively) in cardiovascular disease risk, when comparing tertile T3 to T1.
CONCLUSIONS
Higher intakes of polyphenols, especially of anthocyanins, catechins, and flavonols, were associated with a statistically significant decreased cardiovascular disease risk.
背景
流行病学和实验证据支持膳食多酚对慢性病的保护作用，但仍需要高质量的纵向数据，包括多酚类别的详细信息。我们的目的是在 NutriNet-Santé 队列中研究膳食多酚的总量和单个类别及亚类与主要心血管疾病风险之间的前瞻性关联。
方法
2009 年 5 月至 2017 年 6 月期间，共纳入 84158 名至少完成 3 次 24 小时膳食记录的参与者。通过将 24 小时膳食记录中的食物消耗数据与 Phenol-Explorer 多酚成分数据库进行匹配，获得个体多酚的摄入量。使用多变量 Cox 比例风险模型，比较多酚类别和亚类的三分位数 T3 与 T1，描述膳食多酚与心血管疾病发病率之间的关系。
结果
在中位数为 4.9 年的随访期间，诊断出 602 例主要心血管事件。花色苷、儿茶素和类黄酮的摄入量与心血管疾病风险呈显著负相关（花色苷：风险比（HR）=0.98（0.96⁻0.99），=0.03，HR=0.66（0.52⁻0.83），=0.0003；儿茶素：HR=0.98（0.96⁻0.99），=0.02，HR=0.74（0.60⁻0.91），=0.004；类黄酮：HR=0.94（0.90⁻0.99），=0.02，HR=0.75（0.61⁻0.94），=0.006）。二氢查尔酮、原花青素、二氢黄酮醇、羟基苯甲酸和白藜芦醇的摄入量也与心血管疾病风险降低相关（分别降低 13%、19%、24%、24%和 27%），当比较三分位数 T3 与 T1 时。
结论
较高的多酚摄入量，尤其是花色苷、儿茶素和类黄酮，与心血管疾病风险的统计学显著降低相关。
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