食物来源的细胞外囊泡作为多生物活性复合物及其多样的健康效应

Department of Food Science and Biotechnology of Animal Resources, Konkuk University, Seoul 05029, Republic of Korea.

Antioxidants (Basel). 2023 Oct 13;12(10):1862. doi: 10.3390/antiox12101862.

Extracellular vesicles (EVs) are membrane-bound organelles that are generally released by eukaryotic cells and enclose various cellular metabolic information, such as RNA, meta-proteins, and versatile metabolites. The physiological properties and diverse functions of food-derived EVs have been extensively elucidated, along with a recent explosive upsurge in EV research. Therefore, a concise review of the health effects of food-derived EVs is necessary. This review summarizes the structural stability and uptake pathways of food-derived EVs to target cells and their health benefits, including antioxidant, anti-inflammatory, and anticarcinogenic effects, gut microbiome modulation, and intestinal barrier enhancement.

细胞外囊泡（EVs）是膜结合细胞器，通常由真核细胞释放，并包裹各种细胞代谢信息，如RNA、元蛋白质和多种代谢产物。随着近年来EV研究的迅速兴起，食物来源的EVs的生理特性和多样功能已得到广泛阐明。因此，有必要对食物来源的EVs的健康影响进行简要综述。本综述总结了食物来源的EVs对靶细胞的结构稳定性、摄取途径及其健康益处，包括抗氧化、抗炎和抗癌作用、肠道微生物群调节以及肠道屏障增强。