a Department of Physiology & Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences , University of Manitoba , Winnipeg , Canada.
b Department of Applied Computer Science , University of Winnipeg , Winnipeg , Canada.
RNA Biol. 2019 Feb;16(2):155-159. doi: 10.1080/15476286.2018.1564617. Epub 2019 Jan 6.
The family of heterogeneous ribonucleoproteins (hnRNPs) have multiple functions in RNA metabolism. In recent years, several hnRNPs have also been shown to be essential for the maintenance of transcriptome integrity, by preventing intronic cryptic splicing signals from mis-splicing of many endogeneous pre-mRNA transcripts. Here we discuss the possibility for a general role of this family of proteins and their expansion in transcriptome protection.
异质核核糖核蛋白（hnRNPs）家族在 RNA 代谢中具有多种功能。近年来，一些 hnRNPs 也被证明对于维持转录组完整性至关重要，它们可以防止许多内源性前体 mRNA 转录本的内含子隐匿剪接信号发生错误剪接。本文讨论了该蛋白家族发挥一般作用及其在转录组保护中扩展的可能性。
