School of Medicine, Jiamusi University, Jiamusi 154007, China.
School of Medicine, Dalian University, Dalian 116622, China.
Biomolecules. 2023 Sep 27;13(10):1454. doi: 10.3390/biom13101454.
Autophagy is a highly conserved intracellular degradation pathway in eukaryotic organisms, playing an adaptive role in various pathophysiological processes throughout evolution. Inflammation is the immune system's response to external stimuli and tissue damage. However, persistent inflammatory reactions can lead to a range of inflammatory diseases and cancers. The interaction between autophagy and inflammation is particularly evident during viral infections. As a crucial regulator of inflammation, autophagy can either promote or inhibit the occurrence of inflammatory responses. In turn, inflammation can establish negative feedback loops by modulating autophagy to suppress excessive inflammatory reactions. This interaction is pivotal in the pathogenesis of viral diseases. Therefore, elucidating the regulatory roles of autophagy and inflammation in viral infections will significantly enhance our understanding of the mechanisms underlying related diseases. Furthermore, it will provide new insights and theoretical foundations for disease prevention, treatment, and drug development.
自噬是真核生物中一种高度保守的细胞内降解途径，在进化过程中的各种病理生理过程中发挥适应性作用。炎症是免疫系统对外部刺激和组织损伤的反应。然而，持续的炎症反应会导致一系列炎症性疾病和癌症。自噬和炎症之间的相互作用在病毒感染中尤为明显。自噬作为炎症的关键调节因子，可以促进或抑制炎症反应的发生。反过来，炎症可以通过调节自噬来抑制过度的炎症反应，建立负反馈回路。这种相互作用在病毒疾病的发病机制中至关重要。因此，阐明自噬和炎症在病毒感染中的调节作用将极大地增强我们对相关疾病发病机制的理解。此外，它将为疾病预防、治疗和药物开发提供新的见解和理论基础。
