Department of Physiology, Medical University of Bialystok, 15-089 Bialystok, Poland.
Department of Pharmacology, Medical University of Bialystok, 15-089 Bialystok, Poland.
Nutrients. 2023 Oct 12;15(20):4350. doi: 10.3390/nu15204350.
Cannabigerol (CBG), a non-psychotropic phytocannabinoid found in plants, has been the focus of recent studies due to its potential therapeutic properties. We proposed that by focusing on sphingolipid metabolism, which plays a critical role in insulin signaling and the development of insulin resistance, CBG may provide a novel therapeutic approach for metabolic disorders, particularly insulin resistance.
In a rat model of insulin resistance induced by a high-fat, high-sucrose diet (HFHS), we aimed to elucidate the effect of intragastrically administered CBG on hepatic sphingolipid deposition and metabolism. Moreover, we also elucidated the expression of sphingolipid transporters and changes in the sphingolipid concentration in the plasma.
The results, surprisingly, showed a lack of changes in de novo ceramide synthesis pathway enzymes and significant enhancement in the expression of enzymes involved in ceramide catabolism, which was confirmed by changes in hepatic sphingomyelin, sphinganine, sphingosine-1-phosphate, and sphinganine-1-phosphate concentrations.
The results suggest that CBG treatment may modulate sphingolipid metabolism in the liver and plasma, potentially protecting the liver against the development of metabolic disorders such as insulin resistance.
大麻萜酚（CBG）是植物中发现的一种非精神活性植物大麻素，由于其潜在的治疗特性，最近成为研究的焦点。我们提出，通过关注在胰岛素信号转导和胰岛素抵抗发展中起关键作用的鞘脂代谢，CBG 可能为代谢紊乱，特别是胰岛素抵抗提供一种新的治疗方法。
在高脂肪、高蔗糖饮食（HFHS）诱导的胰岛素抵抗大鼠模型中，我们旨在阐明胃内给予 CBG 对肝鞘脂沉积和代谢的影响。此外，我们还阐明了鞘脂转运蛋白的表达和血浆中鞘脂浓度的变化。
出乎意料的是，结果显示从头合成神经酰胺途径酶没有变化，而参与神经酰胺分解代谢的酶的表达显著增强，这通过肝鞘磷脂、神经酰胺、神经酰胺-1-磷酸和神经酰胺-1-磷酸浓度的变化得到证实。
结果表明，CBG 治疗可能调节肝脏和血浆中的鞘脂代谢，可能保护肝脏免受代谢紊乱如胰岛素抵抗的发展。
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