4th Military Teaching Hospital, 50-981 Wroclaw, Poland.
Faculty of Environmental Engineering, Wroclaw University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wroclaw, Poland.
Int J Mol Sci. 2024 Oct 19;25(20):11258. doi: 10.3390/ijms252011258.
This review provides an overview of cannabis-based phytocannabinoids, focusing on their mechanisms of action, therapeutic applications, and production processes, along with the environmental factors that affect their quality and efficacy. Phytocannabinoids such as THC (∆-tetrahydrocannabinol), CBD (cannabidiol), CBG (cannabigerol), CBN (cannabinol), and CBC (cannabichromene) exhibit significant therapeutic potential in treating various physical and mental health conditions, including chronic pain, epilepsy, neurodegenerative diseases, skin disorders, and anxiety. The cultivation of cannabis plays a crucial role in determining cannabinoid profiles, with indoor cultivation offering more control and consistency than outdoor methods. Environmental factors such as light, water, temperature, humidity, nutrient management, CO, and the drying method used are key to optimizing cannabinoid content in inflorescences. This review outlines the need for broader data transfer between the health industry and technological production, especially in terms of what concentration and cannabinoid ratios are effective in treatment. Such data transfer would provide cultivators with information on what environmental parameters should be manipulated to obtain the required final product.
这篇综述概述了基于大麻的植物大麻素，重点介绍了它们的作用机制、治疗应用和生产工艺，以及影响其质量和功效的环境因素。大麻素如 THC（∆-四氢大麻酚）、CBD（大麻二酚）、CBG（大麻萜酚）、CBN（大麻酚）和 CBC（大麻色烯）在治疗各种身心健康状况方面具有显著的治疗潜力，包括慢性疼痛、癫痫、神经退行性疾病、皮肤疾病和焦虑症。大麻的种植在确定大麻素图谱方面起着至关重要的作用，室内种植比室外方法提供了更多的控制和一致性。环境因素如光、水、温度、湿度、养分管理、CO2 和使用的干燥方法是优化花序中大麻素含量的关键。本综述概述了在健康产业和技术生产之间更广泛的数据转移的必要性，特别是在什么浓度和大麻素比例在治疗中有效的问题上。这种数据转移将为种植者提供有关应操纵哪些环境参数以获得所需最终产品的信息。
