Department of Public Health, Yonsei University Graduate School, Seoul, Republic of Korea.
Healthcare Data Promotion Division, Bureau of Health Industry, Ministry of Health and Welfare, Sejong, Republic of Korea.
Ophthalmic Epidemiol. 2021 Dec;28(6):488-494. doi: 10.1080/09286586.2021.1879172. Epub 2021 Jan 31.
: We aimed to investigate the prevalence and risk factors of dry eye syndrome (DES) among a population-based cohort study.: This cross-sectional study was conducted on 475 subjects (184 men and 291 women) enrolled in the Study Group for Environmental Eye Disease at July 2013. Using the ocular surface disease index (OSDI), we measured the DES severity and defined DES as OSDI score ≥13. Current symptoms of DES and possible risk factors such as body mass index, occupations, comorbidities, exercise, smoking and drinking status were assessed by multivariate logistic regression.: Prevalence of DES was significantly higher in women (52.6%) than in men (41.9%) ( < .001). Compared to white-collar workers, blue-collar workers and unemployed persons showed significantly higher DES prevalence and severity. Compared to those with low BMI (<23.0 kg/m), people with extremely high BMI (≥30.0 kg/m) had significantly higher odds ratio (OR) of having DES after fully adjusted for sex, age, hypertension, diabetes, menopausal status, hormone replacement therapy, occupation, and lifestyle factors (OR: 2.83, 95% confidence interval: 1.04-7.71).: We found some novel factors which have been unknown to the relationship with DES through the five years observation of the cohort. The positive associations of unemployment status, blue-collar work, alcohol habit, and obesity with DES suggests a person's comprehensive condition, not individual factors, contribute significantly in developing DES. Further studies will be helpful to understand the underlying mechanisms.
我们旨在通过一项基于人群的队列研究，调查干眼症（DES）在人群中的患病率和危险因素。本横断面研究于 2013 年 7 月对参加环境眼病研究小组的 475 名受试者（184 名男性和 291 名女性）进行。我们使用眼表面疾病指数（OSDI）测量 DES 的严重程度，并将 OSDI 评分≥13 定义为 DES。通过多变量逻辑回归评估当前 DES 症状和可能的危险因素，如体重指数、职业、合并症、运动、吸烟和饮酒状况。DES 的患病率在女性（52.6%）明显高于男性（41.9%）（<.001）。与白领工人相比，蓝领工人和失业人员的 DES 患病率和严重程度明显更高。与 BMI<23.0kg/m 的人相比，BMI 极高（≥30.0kg/m）的人在充分调整性别、年龄、高血压、糖尿病、绝经状态、激素替代疗法、职业和生活方式因素后，DES 的比值比（OR）明显更高（OR：2.83，95%置信区间：1.04-7.71）。通过对队列的五年观察，我们发现了一些与 DES 相关的未知新因素。失业状况、蓝领工作、饮酒习惯和肥胖与 DES 的阳性关联表明，一个人的综合状况，而不是个体因素，对 DES 的发生有重要影响。进一步的研究将有助于了解潜在的机制。
