Kim Young-Hoon, Lee Jun-Seok, Ha Kee-Yong, Kim Sang-Il, Jung Ho-Young, Kim Geon-U, Joh Yongwon, Park Hyung-Youl
Department of Orthopedic Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Department of Orthopedic Surgery, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 03312, Republic of Korea.
Bioengineering (Basel). 2023 Sep 22;10(10):1114. doi: 10.3390/bioengineering10101114.
(1) Background: Recently, -derived recombinant human bone morphogenetic protein-2 (-derived rhBMP-2) has been increasingly applied to different types of spinal surgeries and reported to achieve successful fusion. This pilot study aimed to evaluate the clinical efficacy and safety of rhBMP-2 in patients undergoing posterior instrumented fusions for unstable spinal fractures. (2) Methods: This study included ten consecutive patients undergoing spinal surgery using -derived rhBMP-2 with more than one year of follow-up. Radiologic outcomes were compared, including the average fracture healing period, local kyphosis correction, and clinical outcomes between preoperative and the last follow-up. (3) Results: The average time of radiographic union was 99.9 ± 45.4 (62-192) days, with an average use of 5.2 ± 3.9 months of anabolic agents. Radiologic parameters such as anterior vertebral height and vertebral wedge angle were significantly corrected postoperatively and at the last follow-up. Clinical outcomes other than leg pain were significantly improved after the surgery. In addition, four patients with preoperative neurologic deficits showed improved neurologic status. (4) Conclusions: Combined with the anabolic agents, applying -derived rhBMP-2 to the fractured vertebral body could be an effective surgical treatment for unstable spinal fractures. Further trials are needed to validate this result.
(1) 背景：最近，[具体来源]衍生的重组人骨形态发生蛋白-2（[具体来源]衍生的rhBMP-2）已越来越多地应用于不同类型的脊柱手术，并据报道取得了成功的融合效果。这项前瞻性研究旨在评估rhBMP-2在接受后路器械融合治疗不稳定脊柱骨折患者中的临床疗效和安全性。(2) 方法：本研究纳入了连续10例接受使用[具体来源]衍生的rhBMP-2的脊柱手术且随访超过一年的患者。比较了影像学结果，包括平均骨折愈合时间、局部后凸矫正情况，以及术前和末次随访之间的临床结果。(3) 结果：影像学愈合的平均时间为99.9±45.4（62 - 192）天，合成代谢药物的平均使用时间为5.2±3.9个月。术前和末次随访时，诸如椎体前缘高度和椎体楔角等影像学参数得到了显著矫正。除腿痛外的临床结果在术后有显著改善。此外，4例术前存在神经功能缺损的患者神经功能状态得到改善。(4) 结论：联合使用合成代谢药物，将[具体来源]衍生的rhBMP-2应用于骨折椎体可能是治疗不稳定脊柱骨折的一种有效手术方法。需要进一步的试验来验证这一结果。
