胰岛β细胞分泌功能与胆囊结石病的相关性：一项基于中国初诊2型糖尿病患者的回顾性研究。

The Correlation between Islet β Cell Secretion Function and Gallbladder Stone Disease: A Retrospective Study Based on Chinese Patients with Newly Diagnosed Type 2 Diabetes Mellitus.

作者信息

Wu Tiantian, Wang Qiang, Pu Changsheng, Zhang Keming

机构信息

Department of Hepatobiliary Surgery, Peking University International Hospital, Beijing 100001, China.

出版信息

Biomedicines. 2023 Oct 19;11(10):2840. doi: 10.3390/biomedicines11102840.

DOI:10.3390/biomedicines11102840

PMID:37893213

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10603909/

Abstract

BACKGROUND

This study aimed to analyze the correlation between islet β cell function and gallbladder stone (GBS) in newly diagnosed type 2 diabetes mellitus (T2DM) patients.

METHODS

A total of 438 newly diagnosed T2DM patients in Peking University International Hospital from January 2017 to August 2022 were retrospectively analyzed and divided into a non-GBS group and a GBS group.

RESULTS

(1) The homeostasis model assessment of the insulin resistance (HOMA-IR) of the GBS group was higher than that of the non-GBS group ( < 0.05), while the homeostasis model assessment of β cell (HOMA-β), disposition index (DI0), and Matsuda index of the GBS group were lower than those of the non-GBS group (all < 0.05). (2) For male patients, HOMA-IR is an independent risk factor for GBS (OR = 2.00, 95% CI:1.03, 3.88, < 0.05), and the Matsuda index value is a protective factor for GBS (OR = 0.76, 95% CI:0.60, 0.96, < 0.05). For female patients, HOMA-IR is an independent risk factor for GBS (OR = 2.80, 95% CI:1.03, 7.58, < 0.05) and the Matsuda index value is a protective factor for GBS (OR = 0.59, 95% CI:0.39, 0.90, < 0.05). (3) For male patients, the area under curve (AUC) for predicting GBS was 0.77 (95% CI 0.67, 0.87), with a specificity of 75.26%, a sensitivity of 80.00%, and an accuracy of 75.64%. For female patients, the AUC for predicting GBS was 0.77 (95% CI 0.63, 0.88), with a specificity of 79.63%, a sensitivity of 71.43%, and an accuracy of 78.69%.

CONCLUSIONS

Insulin resistance may be an independent risk factor for the incidence of GBS in patients with newly diagnosed T2DM, both male or female, which provides a new clinical basis and research direction for the prevention and treatment of GBS in patients with T2DM. This study has established a predictive model of GBS in T2DM and found it to be accurate, thus representing an effective tool for the early prediction of GBS in patients with T2DM.

摘要

背景

本研究旨在分析新诊断2型糖尿病（T2DM）患者胰岛β细胞功能与胆囊结石（GBS）之间的相关性。

方法

回顾性分析2017年1月至2022年8月北京大学国际医院438例新诊断的T2DM患者，并将其分为非GBS组和GBS组。

结果

（1）GBS组胰岛素抵抗的稳态模型评估（HOMA-IR）高于非GBS组（<0.05），而GBS组β细胞稳态模型评估（HOMA-β）、处置指数（DI0）和松田指数低于非GBS组（均<0.05）。（2）对于男性患者，HOMA-IR是GBS的独立危险因素（OR = 2.00，95%CI：1.03，3.88，<0.05），松田指数值是GBS的保护因素（OR = 0.76，95%CI：0.60，0.96，<0.05）。对于女性患者，HOMA-IR是GBS的独立危险因素（OR = 2.80，95%CI：1.03，7.58，<0.05），松田指数值是GBS的保护因素（OR = 0.59，95%CI：0.39，0.90，<0.05）。（3）对于男性患者，预测GBS的曲线下面积（AUC）为0.77（95%CI 0.67，0.87），特异性为75.26%，敏感性为80.00%，准确性为75.64%。对于女性患者，预测GBS的AUC为0.77（95%CI 0.63，0.88），特异性为79.63%，敏感性为71.43%，准确性为78.69%。