苏丹胆结石患者中糖尿病、代谢综合征及相关危险因素的患病率：一项横断面调查
The prevalence of diabetes and metabolic syndrome and associated risk factors in Sudanese individuals with gallstones: a cross sectional survey.
作者信息
Almobarak Ahmed Omer, Jervase Ayat, Fadl Aza Abdelrahman, Garelnabi Nur Ibrahim Ali, Hakem Suzan Al, Hussein Tarig Mohamed, Ahmad Amro Ahmad Aljack, Ahmed Inas Salah El-den, Badi Safaa, Ahmed Mohamed H
机构信息
Department of Pathology, Faculty of Medicine, University of Medical Sciences and Technology, Khartoum, Sudan.
Public and Tropical Health Program, Graduate College, University of Medical Sciences and Technology, Khartoum, Sudan.
出版信息
Transl Gastroenterol Hepatol. 2020 Apr 5;5:14. doi: 10.21037/tgh.2019.10.09. eCollection 2020.
BACKGROUND
The gallstones are common health problem across the world with huge financial burden on health authorities. Obesity and insulin resistance are associated with risk of gallstones disease (GSD). The aim of this study was to assess the prevalence of metabolic syndrome (MetS) and diabetes and associated risk factors in Sudanese patients with gallstones.
METHODS
A prospective cross-sectional study, enrolled patients with gallstones attending Ibn Sina Specialized Teaching Hospital for gastrointestinal and hepatobiliary diseases. A structured questionnaire was applied, anthropometric measures were taken, and blood tested for HbA1c, fasting glucose and lipid profile. Data was analysed using SPSS version 23.
RESULTS
A total number of 151 participants were recruited in the study, 71 of them were ultrasound confirmed GSD patients, and the other 80 were controls without GSD over a period of six months. The prevalence of the MetS and diabetes was 30% and 23.9% respectively. Borderline diabetes was 16.9% and overweight and obesity constituted more than half of the sample 59.6%. Using Chi-Square test, a statistically significant association was found between MetS and HDL, TG, LDL level, waist circumference and blood pressure (BP). Absolute predictors and the risk factors for gallstone disease were waist circumference, age, HbA1c and LDL.
CONCLUSIONS
The prevalence of MetS and diabetes among gallstone patients was 30% and 23.9% respectively. Absolute predictors and the risk factors for gallstone disease were waist circumference, age, HbA1c and LDL.
背景
胆结石是全球常见的健康问题，给卫生当局带来巨大经济负担。肥胖和胰岛素抵抗与胆结石疾病（GSD）风险相关。本研究旨在评估苏丹胆结石患者中代谢综合征（MetS）和糖尿病的患病率及相关危险因素。
方法
一项前瞻性横断面研究，纳入在伊本·西那专科医院就诊的胃肠道和肝胆疾病胆结石患者。应用结构化问卷，进行人体测量，并检测糖化血红蛋白（HbA1c）、空腹血糖和血脂谱。使用SPSS 23版软件进行数据分析。
结果
在六个月的时间里，共招募了151名参与者，其中71名经超声确诊为GSD患者，另外80名是无GSD的对照组。MetS和糖尿病的患病率分别为30%和23.9%。糖尿病前期为16.9%，超重和肥胖占样本的一半以上，为59.6%。使用卡方检验发现，MetS与高密度脂蛋白（HDL）、甘油三酯（TG）、低密度脂蛋白（LDL）水平、腰围和血压（BP）之间存在统计学显著关联。胆结石疾病的绝对预测因素和危险因素是腰围、年龄、HbA1c和LDL。
结论
胆结石患者中MetS和糖尿病的患病率分别为30%和23.9%。胆结石疾病的绝对预测因素和危险因素是腰围、年龄、HbA1c和LDL。
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