基于固定在碳纳米管糊电极上的铋用于体内神经信号检测的神经递质测定法。
Neurotransmitter Assay for In Vivo Nerve Signal Detection Using Bismuth Immobilized on a Carbon Nanotube Paste Electrode.
作者信息
Choi Jongwan, Min Jiwon, Kim Jason Sahngwook, Park Jung Hyun, Ly SuwYoung
机构信息
Department of Chemistry and Life Science, Sahmyook University, Seoul 01795, Republic of Korea.
College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA.
出版信息
Micromachines (Basel). 2023 Oct 2;14(10):1899. doi: 10.3390/mi14101899.
BACKGROUND
Voltammetric analysis of the neurotransmitter epinephrine (EP) was performed using bismuth immobilized on a carbon nanotube paste electrode (BCE), whose properties were compared with those of a carbon nanotube paste electrode (CE). BCE was found to be more efficient in detecting EP.
METHODS
The analytical parameters used were 0.3 V square-wave (SW) stripping voltammetric amplitude, 400 Hz frequency, -0.8 V initial potential, and 0.015 V increment potential. The optimized conditions were applied to an assay of a carp's front fin.
RESULTS
A BCE was inserted into a carp's front fin muscle, and a stimulus was given every 50 s. This circuit is easy to use and does not require much analytical preparation time.
CONCLUSIONS
The working electrode is miniscule, and its detection limit is very low. The in vivo muscle's chronoamperometric nerve currents were analyzed. These results have potential for applications in medical diagnostics, pharmaceuticals, interface controllers, and other fields.
背景
使用固定在碳纳米管糊电极（BCE）上的铋对神经递质肾上腺素（EP）进行伏安分析，并将其性能与碳纳米管糊电极（CE）的性能进行比较。发现BCE在检测EP方面更有效。
方法
所使用的分析参数为0.3 V方波（SW）溶出伏安法振幅、400 Hz频率、-0.8 V初始电位和0.015 V增量电位。将优化条件应用于鲤鱼前鳍的检测。
结果
将BCE插入鲤鱼前鳍肌肉中，每50秒给予一次刺激。该电路易于使用，不需要太多分析准备时间。
结论
工作电极极小，其检测限非常低。对体内肌肉的计时电流神经电流进行了分析。这些结果在医学诊断、制药、接口控制器和其他领域具有应用潜力。
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