对副球孢子菌病病原体抗体交叉反应以及相关真菌物种的重新评估。
Re-Evaluation of the Cross-Reactions of the Antibody against the Causative Agent for Paracoccidioidomycosis Ceti; and the Related Fungal Species.
作者信息
Kanegae Hikaru, de Souza Suguiura Igor Massahiro, Tashiro Rentaro, Konno Toshihiro, Hou De-Xing, Sano Ayako, Eto Takeshi, Ueda Keiichi, Hossain Md Amzad
机构信息
The United Graduate School of Agricultural Sciences, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-0065, Japan.
Department of Pathological Sciences, State University of Londrina, P.O. Box 10011, Londrina 86057-970, PR, Brazil.
出版信息
Microorganisms. 2023 Sep 28;11(10):2428. doi: 10.3390/microorganisms11102428.
Paracoccidioidomycosis ceti (PCM-C) is a chronic granulomatous keloidal dermatitis in cetaceans that has been reported worldwide and is caused by . Serological cross-reactions among highly pathogenic fungal infections and related diseases have been reported. However, the true cross-reaction of antibodies against has remained unknown due to the use of positive control sera from infected dolphins. This study aimed to re-evaluate antibodies from mechanically dislodged fungal cells in the infected tissue of a PCM-C case and demonstrate the actual cross-reaction. The results revealed a limited cross-reaction between PCM-C and paracoccidioidomycosis, while the antibodies did not react with other pathogens such as , , and . Thus, the method for evaluation of the antibody against PCM-C is reliable, and there is potential for epidemiological study.
鲸类副球孢子菌病（PCM-C）是一种鲸类的慢性肉芽肿性瘢痕疙瘩性皮炎，已在全球范围内报道，由……引起。高致病性真菌感染及相关疾病之间的血清学交叉反应已有报道。然而，由于使用来自感染海豚的阳性对照血清，针对……的抗体的真正交叉反应仍不清楚。本研究旨在重新评估PCM-C病例感染组织中机械去除的真菌细胞的抗体，并证明实际的交叉反应。结果显示PCM-C与副球孢子菌病之间存在有限的交叉反应，而这些抗体与其他病原体如……、……和……不发生反应。因此，评估针对PCM-C抗体的方法是可靠的，并且有进行流行病学研究的潜力。
Zotero 插件