暴露于乙醇和吡唑后的鸡胚胎发育
Chick embryonic development following exposure to ethanol and pyrazole.
作者信息
Gilani S H, Sachdev R, Persaud T V
出版信息
Anat Anz. 1986;162(2):79-82.
PMID:3789414
Abstract
The mechanism of alcohol-induced dysmorphogenesis is not clear. Pyrazole is a potent inhibitor of alcohol dehydrogenase. Treatment of chick embryos at 96 h incubation with pyrazole (0.1 mg) and ethanol (0.1 ml, 40-60% v/v) enhanced the embryopathic response, compared with individual treatments. The results suggest that ethanol itself is embryotoxic.
摘要
酒精诱导畸形发生的机制尚不清楚。吡唑是一种有效的乙醇脱氢酶抑制剂。与单独处理相比，在孵化96小时时用吡唑（0.1毫克）和乙醇（0.1毫升，40-60%体积/体积）处理鸡胚增强了胚胎病反应。结果表明乙醇本身具有胚胎毒性。
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