Gracia-Cazaña T, Salazar N, Zamarrón A, Mascaraque M, Lucena S R, Juarranz Á
Unidad de Dermatología, Hospital de Barbastro, Barbastro, Huesca, España; Instituto Aragonés de Ciencias de la Salud, Zaragoza, España.
Departamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid, España.
Actas Dermosifiliogr. 2016 Nov;107(9):740-750. doi: 10.1016/j.ad.2016.04.020. Epub 2016 Jul 18.
A wide range of treatments is now available for nonmelanoma skin cancer, including 5-fluorouracil, ingenol mebutate, imiquimod, diclofenac, photodynamic therapy, methotrexate, cetuximab, vismodegib, and radiotherapy. All are associated with high clinical and histologic response rates. However, some tumors do not respond due to resistance, which may be primary or acquired. Study of the resistance processes is a broad area of research that aims to increase our understanding of the nature of each tumor and the biologic features that make it resistant, as well as to facilitate the design of new therapies directed against these tumors. In this second article, having covered the topical treatments of nonmelanoma skin cancer, we review resistance to other nonsurgical treatments, such as monoclonal antibodies against basal and squamous cell carcinomas, intralesional chemotherapy, photodynamic therapy, and radiotherapy.
目前有多种治疗方法可用于非黑色素瘤皮肤癌，包括5-氟尿嘧啶、咪喹莫特、双氯芬酸、光动力疗法、甲氨蝶呤、西妥昔单抗、维莫德吉和放射疗法。所有这些治疗方法都具有较高的临床和组织学缓解率。然而，一些肿瘤由于耐药性而无反应，这种耐药性可能是原发性的或获得性的。对耐药过程的研究是一个广泛的研究领域，旨在加深我们对每种肿瘤的本质以及使其产生耐药性的生物学特征的理解，并促进针对这些肿瘤的新疗法的设计。在第二篇文章中，我们在介绍了非黑色素瘤皮肤癌的局部治疗方法后，将综述对其他非手术治疗方法的耐药性，如针对基底细胞癌和鳞状细胞癌的单克隆抗体、瘤内化疗、光动力疗法和放射疗法。
