Nicaise Yvan, Delmas Caroline, Cohen-Jonathan-Moyal Elisabeth, Seva Catherine
Centre de Recherche en Cancérologie de Toulouse, Toulouse, Occitanie, France.
Institut universitaire du cancer de Toulouse Oncopole, Toulouse, Occitanie, France.
MicroPubl Biol. 2025 Jul 8;2025. doi: 10.17912/micropub.biology.001613. eCollection 2025.
The recurrence of glioblastoma can be attributed to the high invasiveness and resistance of glioblastoma stem cells (GSCs). Therefore, it is crucial to investigate the molecular mechanisms that drive the agressiveness of these cells. This research focuses on the actin-associated protein PDLIM3 that we found overexpressed in GBM and in highly invasive GSCs. Suppressing PDLIM3 expression with targeted siRNAs significantly decreases cell invasion. Additionally, our findings highlight that PDLIM3 is essential for GSCs in forming neurospheres. This research provides the first evidence that PDLIM3 may contribute to the aggressiveness of glioblastoma by facilitating GSCs sphere formation and enhancing their invasiveness.
胶质母细胞瘤的复发可归因于胶质母细胞瘤干细胞（GSCs）的高侵袭性和耐药性。因此，研究驱动这些细胞侵袭性的分子机制至关重要。本研究聚焦于肌动蛋白相关蛋白PDLIM3，我们发现其在胶质母细胞瘤和高侵袭性GSCs中过表达。用靶向小干扰RNA抑制PDLIM3表达可显著降低细胞侵袭。此外，我们的研究结果表明，PDLIM3对GSCs形成神经球至关重要。本研究首次证明，PDLIM3可能通过促进GSCs球形成和增强其侵袭性，导致胶质母细胞瘤的侵袭性。
