Laboratory of Multiphasic Polymeric Materials, Départment of Process Engineering, Faculty of Technology, University Ferhat Abbas of Setif 1, Setif 19000, Algeria.
Laboratory of Applied Microbiology, Faculty of Natural and Life Sciences, University of Ferhat Abbas Setif 1, Setif 19000, Algeria.
Molecules. 2023 Oct 18;28(20):7153. doi: 10.3390/molecules28207153.
, a therapeutic plant mentioned in the ancient Algerian pharmacopeia, specifically two species belonging to the family, . and . , were investigated in this study for their antibacterial, antioxidant, and anti-inflammatory properties. The study used aqueous extracts (AE) obtained from these plants, and the extraction yields were found to be different. The in vitro antibacterial activity was evaluated using a disc diffusion assay against three typical bacterial strains. The results showed that the two extracts were effective against all three strains. Both extracts displayed significant antioxidant activity compared to BHT. The anti-inflammatory impact was evaluated using a protein (BSA) inhibition denaturation test. The . extract was found to inhibit inflammation by 85% at a concentration of 250 µg/mL, significantly higher than the Aspirin. All phytoconstituents present good pharmacokinetic characteristics without toxicity except very slight toxicity of terpineol and cineol and a maximum binding energy of -7.53 kcal/mol for its anti-TyrRS activity in silico. The study suggests that the extracts and their primary phytochemicals could enhance the efficacy of antibiotics, antioxidants, and non-steroidal anti-inflammatory drugs (NSAIDs). As pharmaceutical engineering experts, we believe this research contributes to developing natural-based drugs with potential therapeutic benefits.
在古老的阿尔及利亚药典中提到的治疗植物，特别是属于 Asteraceae 科的两种植物， 和 ，在这项研究中因其抗菌、抗氧化和抗炎特性而受到研究。该研究使用从这些植物中获得的水提物（AE），并且发现提取产率不同。体外抗菌活性通过圆盘扩散测定法评估了对三种典型细菌菌株的作用。结果表明，两种提取物对所有三种菌株都有效。两种提取物均显示出与 BHT 相比具有显著的抗氧化活性。使用蛋白质（BSA）抑制变性试验评估了抗炎作用。在 250 µg/mL 的浓度下， 提取物抑制炎症的效果达到 85%，明显高于阿司匹林。除了萜品醇和桉树脑有轻微毒性以及其抗 TyrRS 活性的最大结合能为-7.53 kcal/mol 之外，所有植物成分都具有良好的药代动力学特征。该研究表明，提取物及其主要植物化学物质可以增强抗生素、抗氧化剂和非甾体抗炎药（NSAIDs）的功效。作为制药工程专家，我们相信这项研究有助于开发具有潜在治疗益处的天然药物。
