Mare Liviu, Muresan-Pop Marieta, Purcea Lopes Pompilia Mioara, Turza Alexandru, Borodi Gheorghe, Popescu Violeta
Physics & Chemistry Department, Technical University of Cluj-Napoca, 400114 Cluj-Napoca, Romania.
Interdisciplinary Research Institute in Bio-Nano-Sciences, Babes-Bolyai University, 42 Treboniu Laurian, 400271 Cluj-Napoca, Romania.
Molecules. 2023 Oct 19;28(20):7179. doi: 10.3390/molecules28207179.
Nandrolone (Estr-4-en-17β-ol-3-one) is a derivative of testosterone and a naturally occurring anabolic-androgenic agent which belongs to the steroid group. Crystal structures of four short, medium and long esterified forms of nandrolone, including propionate, phenylpropionate, cypionate and undecanoate were determined using single-crystal X-ray diffraction. Crystal packing, supramolecular features and intermolecular interactions were described based on a quantitative and qualitative Hirshfeld surfaces analysis accompanied by evaluation of crystal energies and intermolecular interactions computation. Also, the solubility of the esters was investigated from a pharmaceutical perspective.
诺龙（雌甾-4-烯-17β-醇-3-酮）是睾酮的衍生物，是一种天然存在的同化激素类药物，属于类固醇类。利用单晶X射线衍射测定了诺龙的四种短链、中链和长链酯化形式（包括丙酸酯、苯丙酸酯、环戊丙酸酯和十一酸酯）的晶体结构。基于定量和定性的 Hirshfeld 表面分析，并结合晶体能量评估和分子间相互作用计算，描述了晶体堆积、超分子特征和分子间相互作用。此外，还从药学角度研究了这些酯类的溶解度。
