Heart, Mind and Body Research Group, Griffith University, Gold Coast, QLD 4222, Australia.
Int J Mol Sci. 2023 Oct 15;24(20):15208. doi: 10.3390/ijms242015208.
Flavonoids are the largest group of polyphenols, represented by many compounds that exhibit high anticancer properties. Quercetin (Q) and its main derivatives (rutin, quercitrin, isoquercitrin, isorhamnetin, tamarixetin, rhamnetin, and hyperoside) in the class of flavonols have been documented to exert anticancer activity. Q has been shown to be useful in the treatment of non-small cell lung cancer (NSCLC), as demonstrated by in vitro/in vivo studies, due to its antitumor, anti-inflammatory, anti-proliferative, anti-angiogenesis, and apoptotic properties. Some flavonoids (flavone, anthocyanins, and proanthocyanidins) have been demonstrated to be effective in nicotine-induced NSCLC treatment. However, the molecular mechanisms of quercetin derivatives (QDs) in nicotine-induced NSCLC treatment remain unclear. Thus, this review aims to summarize the available literature on the therapeutic effects of QDs in nicotine-induced NSCLC.
类黄酮是多酚类化合物中最大的一组，由许多具有高抗癌特性的化合物组成。类黄酮中的槲皮素（Q）及其主要衍生物（芦丁、槲皮苷、异槲皮苷、异鼠李素、杨梅素、山奈酚和金丝桃苷）已被证明具有抗癌活性。体外/体内研究表明，Q 可用于治疗非小细胞肺癌（NSCLC），因为它具有抗肿瘤、抗炎、抗增殖、抗血管生成和凋亡特性。一些类黄酮（黄酮、花青素和原花青素）已被证明可有效治疗尼古丁诱导的 NSCLC。然而，槲皮素衍生物（QDs）在尼古丁诱导的 NSCLC 治疗中的分子机制尚不清楚。因此，本综述旨在总结关于 QDs 在尼古丁诱导的 NSCLC 治疗中的治疗效果的现有文献。
