高线粒体单倍型多样性在哥伦比亚的三个前西班牙裔群体中被发现。
High Mitochondrial Haplotype Diversity Found in Three Pre-Hispanic Groups from Colombia.
机构信息
Doctoral Program in Biosciences, Human Genetics Group, Faculty of Medicine, University of La Sabana, Chía 250001, Colombia.
Human Genetics & Genomic Medicine, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK.
出版信息
Genes (Basel). 2023 Sep 23;14(10):1853. doi: 10.3390/genes14101853.
The analysis of mitochondrial DNA (mtDNA) hypervariable region (HVR) sequence data from ancient human remains provides valuable insights into the genetic structure and population dynamics of ancient populations. mtDNA is particularly useful in studying ancient populations, because it is maternally inherited and has a higher mutation rate compared to nuclear DNA. To determine the genetic structure of three Colombian pre-Hispanic populations and compare them with current populations, we determined the haplotypes from human bone remains by sequencing several mitochondrial DNA segments. A wide variety of mitochondrial polymorphisms were obtained from 33 samples. Our results support a high population heterogeneity among pre-Hispanic populations in Colombia.
对古代人类遗骸中线粒体 DNA（mtDNA）高变区（HVR）序列数据的分析，为研究古代人群的遗传结构和人口动态提供了有价值的信息。mtDNA 在研究古代人群时特别有用，因为它是母系遗传的，与核 DNA 相比，其突变率更高。为了确定哥伦比亚三个前西班牙裔人群的遗传结构，并将其与当前人群进行比较，我们通过对几个线粒体 DNA 片段进行测序，从人类骨骼遗骸中确定了单倍型。从 33 个样本中获得了广泛的线粒体多态性。我们的研究结果支持哥伦比亚前西班牙裔人群中存在高度的人口异质性。
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