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揭开历史的遗传密码:mtDNA HVS-I 分析揭示了阿布拉山谷的远古历史。

Unraveling the Genetic Threads of History: mtDNA HVS-I Analysis Reveals the Ancient Past of the Aburra Valley.

机构信息

Doctoral Program in Biosciences, Human Genetics Group, Faculty of Medicine, University of La Sabana, Chía 250001, Colombia.

Human Genetics & Genomic Medicine, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK.

出版信息

Genes (Basel). 2023 Nov 2;14(11):2036. doi: 10.3390/genes14112036.

Abstract

This article presents a comprehensive genetic study focused on pre-Hispanic individuals who inhabited the Aburrá Valley in Antioquia, Colombia, between the tenth and seventeenth centuries AD. Employing a genetic approach, the study analyzed maternal lineages using DNA samples obtained from skeletal remains. The results illuminate a remarkable degree of biological diversity within these populations and provide insights into their genetic connections with other ancient and indigenous groups across the American continent. The findings strongly support the widely accepted hypothesis that the migration of the first American settlers occurred through Beringia, a land bridge connecting Siberia to North America during the last Ice Age. Subsequently, these early settlers journeyed southward, crossing the North American ice cap. Of particular note, the study unveils the presence of ancestral lineages from Asian populations, which played a pivotal role in populating the Americas. The implications of these results extend beyond delineating migratory routes and settlement patterns of ancient populations. They also enrich our understanding of the genetic diversity inherent in indigenous populations of the region. By revealing the genetic heritage of pre-Hispanic individuals from the Aburrá Valley, this study offers valuable insights into the history of human migration and settlement in the Americas. Furthermore, it enhances our comprehension of the intricate genetic tapestry that characterizes indigenous communities in the area.

摘要

本文对 10 至 17 世纪生活在哥伦比亚安蒂奥基亚省阿维拉山谷的前西班牙裔个体进行了全面的遗传学研究。该研究采用遗传方法,通过对骨骼遗骸中的 DNA 样本进行分析,研究了母系世系。研究结果揭示了这些人群中存在显著的生物多样性,并深入了解了他们与整个美洲大陆其他古代和本土群体的遗传联系。这些发现有力地支持了一个广为接受的假说,即第一批美洲定居者的迁徙是通过白令海峡进行的,在末次冰期,白令海峡是连接西伯利亚和北美的大陆桥。随后,这些早期定居者向南穿越北美冰盖。值得注意的是,该研究揭示了亚洲人群的祖先世系的存在,这些世系在美洲的人口中发挥了关键作用。这些结果的意义不仅在于描绘了古代人群的迁徙路线和定居模式,还丰富了我们对该地区本土人群固有遗传多样性的理解。通过揭示阿维拉山谷前西班牙裔个体的遗传遗产,本研究为了解人类在美洲的迁移和定居历史提供了有价值的见解。此外,它还增进了我们对该地区本土社区复杂遗传图谱的理解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4346/10670959/451387f67a0c/genes-14-02036-g001.jpg

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