Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA 22903, USA.
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77550, USA.
Genes (Basel). 2023 Sep 30;14(10):1896. doi: 10.3390/genes14101896.
Alternative RNA splicing, a ubiquitous mechanism of gene regulation in eukaryotes, expands genome coding capacity and proteomic diversity. It has essential roles in all aspects of human physiology, including immunity. This review highlights the importance of RNA alternative splicing in regulating immune T cell function. We discuss how mutations that affect the alternative splicing of T cell factors can contribute to abnormal T cell function and ultimately lead to autoimmune diseases. We also explore the potential applications of strategies that target the alternative splicing changes of T cell factors. These strategies could help design therapeutic approaches to treat autoimmune disorders and improve immunotherapy.
可变剪接是真核生物中普遍存在的一种基因调控机制，它可以扩大基因组的编码能力和蛋白质组的多样性。可变剪接在人类生理的各个方面都有重要作用，包括免疫。这篇综述强调了 RNA 可变剪接在调节免疫 T 细胞功能中的重要性。我们讨论了影响 T 细胞因子可变剪接的突变如何导致 T 细胞功能异常，最终导致自身免疫性疾病。我们还探讨了靶向 T 细胞因子可变剪接改变的策略的潜在应用。这些策略可以帮助设计治疗自身免疫性疾病和改善免疫疗法的方法。
