Department of Biotechnological and Applied Clinical Sciences (DISCAB), University of L'Aquila, Via Vetoio, Coppito 2, 67100 L'Aquila, Italy.
Genes (Basel). 2023 Oct 17;14(10):1953. doi: 10.3390/genes14101953.
Metabolism and the immunological state are intimately intertwined, as defense responses are bioenergetically expensive. Metabolic homeostasis is a key requirement for the proper function of immune cell subsets, and the perturbation of the immune-metabolic balance is a recurrent event in many human diseases, including cancer, due to nutrient fluctuation, hypoxia and additional metabolic changes occurring in the tumor microenvironment (TME). Although much remains to be understood in the field of immunometabolism, here, we report the current knowledge on both physiological and cancer-associated metabolic profiles of immune cells, and the main molecular circuits involved in their regulation, highlighting similarities and differences, and emphasizing immune metabolic liabilities that could be exploited in cancer therapy to overcome immune resistance.
代谢和免疫状态密切相关，因为防御反应是非常耗能的。代谢稳态是免疫细胞亚群正常功能的关键要求，而免疫代谢平衡的破坏是许多人类疾病（包括癌症）的常见事件，这是由于肿瘤微环境（TME）中发生的营养波动、缺氧和其他代谢变化。尽管在免疫代谢领域还有很多需要了解的地方，但在这里，我们报告了关于免疫细胞的生理和与癌症相关的代谢特征的最新知识，以及它们调节的主要分子途径，突出了相似性和差异性，并强调了可能在癌症治疗中被利用以克服免疫抵抗的免疫代谢缺陷。
