Riggs T R, Yano Y, Vargish T
Am Surg. 1986 Dec;52(12):654-8.
Previous work has demonstrated that a common opiate agonist, morphine sulfate (MS), causes significant depression of myocardial performance when added to the perfusate of a modified Langendorff isolated rat heart preparation. The same model has been used in this study with the addition of higher concentrations of MS to demonstrate that the aforementioned effects occur in a dose-related fashion. In addition, different anesthetics, sodium pentobarbital (P) or chloral hydrate (CH), were compared and demonstrated that there was no significant difference in results. This implies that there is not an anesthetic-morphine interaction occurring. These results suggest opiate agonist depression of myocardial function acts on opiate receptors, causing primarily a chronotropic effect.
先前的研究表明，一种常见的阿片类激动剂硫酸吗啡（MS），添加到改良的Langendorff离体大鼠心脏灌流液中时，会导致心肌功能显著降低。本研究使用了相同的模型，并添加了更高浓度的MS，以证明上述效应呈剂量相关方式出现。此外，还比较了不同的麻醉剂戊巴比妥钠（P）或水合氯醛（CH），结果表明两者无显著差异。这意味着不存在麻醉剂 - 吗啡相互作用。这些结果表明，阿片类激动剂对心肌功能的抑制作用作用于阿片受体，主要引起变时性效应。
