Samfireag Miruna, Potre Ovidiu, Potre Cristina, Moleriu Radu-Dumitru, Petre Izabella, Borsi Ema, Hoinoiu Teodora, Petre Ion, Popoiu Tudor-Alexandru, Iurciuc Stela, Anghel Andrei
Department of Internal Medicine, Discipline of Clinical Practical Skills, "Victor Babes" University of Medicine and Pharmacy, No. 2 Eftimie Murgu Square, 300041 Timisoara, Romania.
Advanced Cardiology and Hemostaseology Research Center, "Victor Babes" University of Medicine and Pharmacy, No. 2 Eftimie Murgu Square, 300041 Timisoara, Romania.
Life (Basel). 2023 Oct 19;13(10):2082. doi: 10.3390/life13102082.
A thrombophilic woman is more likely to experience difficulties during pregnancy, difficulties that will also affect the development of the newborn. This study aims to compare maternal and newborn characteristics between healthy and thrombophilic pregnancy. The following characteristics were analysed: maternal characteristics (BMI- body mass index, haemostasis parameters, thrombophilia-specific treatment) and newborn characteristics (gestational period, birth weight, the Apgar score). This follow-up study spanning five years, from 2018 to 2022, focuses on a cohort of 500 women who underwent delivery hospitalization in the western region of Romania. The maternal characteristics influence the newborn: the greater the weight of the mother with thrombophilia, the more the chances that the fetus will have a lower birth weight; increasing the dose of LMWH (low molecular weight heparin), connected with the necessity to control the homeostasis parameters, the more likely the fetus will be born with a lower birth weight. A pregnant woman with thrombophilia, treated appropriately, having a normal weight, and not presenting other risk factors independent of thrombophilia, will have a newborn with characteristics similar to a healthy pregnant woman.
患有血栓形成倾向的女性在孕期更有可能遭遇困难,这些困难也会影响新生儿的发育。本研究旨在比较健康妊娠和血栓形成倾向妊娠的母婴特征。分析了以下特征:母亲特征(体重指数、止血参数、血栓形成倾向特异性治疗)和新生儿特征(孕周、出生体重、阿氏评分)。这项为期五年(2018年至2022年)的随访研究聚焦于罗马尼亚西部地区500名接受分娩住院治疗的女性队列。母亲特征会影响新生儿:患有血栓形成倾向的母亲体重越大,胎儿出生体重较低的可能性就越大;随着控制体内平衡参数所需的低分子肝素剂量增加,胎儿出生体重较低的可能性就越大。一名患有血栓形成倾向的孕妇,若得到适当治疗,体重正常,且不存在独立于血栓形成倾向的其他风险因素,其新生儿的特征将与健康孕妇的新生儿相似。