Albocycline Is the Main Bioactive Antifungal Compound Produced by sp. OR6 against .

Verticillium wilt is a soil-borne fungal disease that affects olive trees () and poses a serious threat to their cultivation. The causal agent of this disease is , a pathogen that is difficult to control with conventional methods. Therefore, there is a need to explore alternative strategies for the management of Verticillium wilt. In this study, we aimed to isolate and characterize actinobacteria from the rhizosphere of olive trees that could act as potential biocontrol agents against . We selected a sp. OR6 strain based on its in vitro antifungal activity and its ability to suppress the pathogen growth in soil samples. We identified the main active compound produced by this strain as albocycline, a macrolide polyketide with known antibacterial properties and some antifungal activity. Albocycline was able to efficiently suppress the germination of conidiospores. To our knowledge, this is the first report of albocycline as an effective agent against . Our results suggest that sp. OR6, or other albocycline-producing strains, could be used as a promising tool for the biological control of Verticillium wilt.