Arkhipova Daria M, Ermolaev Vadim V, Baembitova Gulnaz R, Samigullina Aida I, Lyubina Anna P, Voloshina Alexandra D
N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow 119991, Russia.
Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of Russian Academy of Sciences, Kazan 420088, Russia.
Polymers (Basel). 2023 Oct 16;15(20):4097. doi: 10.3390/polym15204097.
In the present study, the synthesis of oxygen-containing quaternary phosphonium salts (oxy-QPSs) was described. Within this work, structure-property relationships of oxy-QPSs were estimated by systematic analysis of physical-chemical properties. The influence of the oxygen-containing substituent was examined by comparing the properties of oxy-QPSs in homology series as well as with phosphonium analog-included alkyl side chains. The crystal structure analysis showed that the oxygen introduction influences the conformation of the side chain of the oxy-QPS. It was found that oxy-QPSs, using an aprotic co-solvent, dimethylsulfoxide (DMSO), can dissolve microcrystalline cellulose. The cellulose dissolution in oxy-QPSs appeared to be dependent on the functional group in the cation and anion nature. For the selected conditions, dissolution of up to 5 wt% of cellulose was observed. The antimicrobial activity of oxy-QPSs under study was expected to be low. The biocompatibility of oxy-QPSs with fermentative microbes was tested on non-pathogenic , , and . This reliably allows one to safely address the combined biomass destruction and enzyme hydrolysis processes in one pot.
在本研究中，描述了含氧季鏻盐（oxy-QPSs）的合成。在这项工作中，通过对物理化学性质的系统分析来评估oxy-QPSs的结构-性质关系。通过比较同系物系列中oxy-QPSs的性质以及与含鏻类似物的烷基侧链，研究了含氧取代基的影响。晶体结构分析表明，氧的引入影响了oxy-QPS侧链的构象。发现使用非质子共溶剂二甲基亚砜（DMSO）的oxy-QPSs可以溶解微晶纤维素。纤维素在oxy-QPSs中的溶解似乎取决于阳离子中的官能团和阴离子的性质。在选定的条件下，观察到高达5 wt%的纤维素溶解。预计所研究的oxy-QPSs的抗菌活性较低。在非致病性的、和上测试了oxy-QPSs与发酵微生物的生物相容性。这可靠地允许人们在一个容器中安全地处理生物质破坏和酶水解的联合过程。
