Department of Family Medicine, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 333, Taiwan.
Department of Medicine, University of California San Diego, San Diego, CA 92093, USA.
Viruses. 2023 Sep 27;15(10):2015. doi: 10.3390/v15102015.
Cervical cancer, a major health concern among women worldwide, is closely linked to human papillomavirus (HPV) infection. This study explores the evolving landscape of HPV molecular epidemiology in Taiwan over a decade (2010-2020), where prophylactic HPV vaccination has been implemented since 2007. Analyzing data from 40,561 vaginal swab samples, with 42.0% testing positive for HPV, we reveal shifting trends in HPV genotype distribution and infection patterns. The 12 high-risk genotypes, in order of decreasing percentage, were HPV 52, 58, 16, 18, 51, 56, 39, 59, 33, 31, 45, and 35. The predominant genotypes were HPV 52, 58, and 16, accounting for over 70% of cases annually. The proportions of high-risk and non-high-risk HPV infections varied across age groups. High-risk infections predominated in sexually active individuals aged 30-50 and were mixed-type infections. The composition of high-risk HPV genotypes was generally stable over time; however, HPV31, 33, 39, and 51 significantly decreased over the decade. Of the strains, HPV31 and 33 are shielded by the nonavalent HPV vaccine. However, no reduction was noted for the other seven genotypes. This study offers valuable insights into the post-vaccine HPV epidemiology. Future investigations should delve into HPV vaccines' effects and their implications for cervical cancer prevention strategies. These findings underscore the need for continued surveillance and research to guide effective public health interventions targeting HPV-associated diseases.
宫颈癌是全球女性面临的主要健康问题之一，与人类乳头瘤病毒（HPV）感染密切相关。本研究探讨了台湾 HPV 分子流行病学在过去十年（2010-2020 年）的演变情况，台湾自 2007 年开始实施预防性 HPV 疫苗接种。对 40561 份阴道拭子样本进行分析，其中 42.0%HPV 检测呈阳性，揭示了 HPV 基因型分布和感染模式的变化趋势。12 种高危型 HPV 按百分比递减的顺序依次为 HPV 52、58、16、18、51、56、39、59、33、31、45 和 35。主要基因型为 HPV 52、58 和 16，每年占病例的 70%以上。高危型和非高危型 HPV 感染的比例因年龄组而异。高危型感染在 30-50 岁有性行为的个体中占主导地位，且为混合感染。高危型 HPV 基因型的组成在一段时间内相对稳定；然而，HPV31、33、39 和 51 在过去十年中显著减少。在这些菌株中，HPV31 和 33 被九价 HPV 疫苗所涵盖。然而，其他七种基因型并未减少。本研究为 HPV 疫苗接种后流行病学提供了有价值的见解。未来的研究应深入探讨 HPV 疫苗的效果及其对宫颈癌预防策略的影响。这些发现强调了需要持续监测和研究，以指导针对 HPV 相关疾病的有效公共卫生干预措施。
