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恒河猴血清阴性的巨细胞病毒经胎盘传播的数学模型。

Mathematical Modeling of Rhesus Cytomegalovirus Transplacental Transmission in Seronegative Rhesus Macaques.

机构信息

Department of Mathematics, Duke University, Durham, NC 27710, USA.

Department of Immunology, Tulane National Primate Research Center, Covington, LA 70433, USA.

出版信息

Viruses. 2023 Oct 1;15(10):2040. doi: 10.3390/v15102040.

DOI:10.3390/v15102040
PMID:37896817
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10611067/
Abstract

Approximately 0.7% of infants are born with congenital cytomegalovirus (CMV), making it the most common congenital infection. About 1 in 5 congenitally infected babies will suffer long-term sequelae, including sensorineural deafness, intellectual disability, and epilepsy. CMV infection is highly species-dependent, and the rhesus CMV (RhCMV) infection of rhesus monkey fetuses is the only animal model that replicates essential features of congenital CMV (cCMV) infection in humans, including placental transmission, fetal disease, and fetal loss. Using experimental data from RhCMV seronegative rhesus macaques inoculated with RhCMV in the late first to early second trimesters of pregnancy, we built and calibrated a mathematical model for the placental transmission of CMV. The model was then used to study the effect of the timing of inoculation, maternal immune suppression, and hyper-immune globulin infusion on the risk of placental transmission in the context of primary and reactivated chronic maternal CMV infection.

摘要

约 0.7%的婴儿出生时患有先天性巨细胞病毒 (CMV)，使其成为最常见的先天性感染。约 1/5 的先天性感染婴儿会出现长期后遗症，包括感觉神经性耳聋、智力残疾和癫痫。CMV 感染高度依赖于物种，恒河猴胎儿的猴 CMV (RhCMV) 感染是唯一能够复制人类先天性 CMV (cCMV) 感染基本特征的动物模型，包括胎盘传播、胎儿疾病和胎儿丢失。利用 RhCMV 血清阴性恒河猴在妊娠第一至第二个三个月晚期接种 RhCMV 的实验数据，我们构建并校准了 CMV 胎盘传播的数学模型。然后，该模型用于研究在原发性和再激活慢性母体 CMV 感染的情况下，接种时间、母体免疫抑制和高免疫球蛋白输注对胎盘传播风险的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56c1/10611067/70c1086d4b6d/viruses-15-02040-g012.jpg
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本文引用的文献

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Viruses. 2021 Nov 16;13(11):2292. doi: 10.3390/v13112292.
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Innate immune defenses at the maternal-fetal interface.母体-胎儿界面的固有免疫防御。
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Infections at the maternal-fetal interface: an overview of pathogenesis and defence.母胎界面感染：发病机制与防御概述。
恒河猴模型中，初次母体感染后母体巨细胞病毒特异性抗体反应和病毒载量与垂直传播风险的关系。
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Immune Profile of the Normal Maternal-Fetal Interface in Rhesus Macaques and Its Alteration Following Zika Virus Infection.恒河猴正常母胎界面的免疫特征及其感染寨卡病毒后的变化。
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A Trial of Hyperimmune Globulin to Prevent Congenital Cytomegalovirus Infection.巨细胞病毒免疫球蛋白预防先天性巨细胞病毒感染的临床试验
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