Clinical and Rehabilitative MS Research, Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center, Hamburg, Germany.
Department of Clinical Psychology, University of Bern, Bern, Switzerland.
Mult Scler. 2023 Dec;29(14):1709-1720. doi: 10.1177/13524585231201089. Epub 2023 Oct 28.
Persons with multiple sclerosis (pwMS) might be particularly well suited to benefit from digital health applications because they are, on average, younger and less severely disabled than patients with many other chronic diseases. Many digital health applications for pwMS have been developed.
Analysis of the evidence of digital health applications to improve health outcomes from a patient perspective.
A systematic review was performed on all randomized controlled trials (RCTs) that have studied mobile health interventions for pwMS, that is, which can be applied with a smartphone, tablet, or laptop to improve patient-reported outcomes.
Of the 1127 articles identified in the literature search, 13 RCTs fit the inclusion criteria. Two trials studied messaging systems, two depression interventions, one addressed MS fatigue, five cognition, and three mobility issues, of which two focused on spasticity management. One trial aimed to enhance physical activity. Most were pilot studies that cannot yield definitive conclusions regarding efficacy. One depression intervention and one fatigue intervention showed significant results across several outcomes.
Several mobile self-guided digital health applications for pwMS have been tested in RCTs, and two interventions targeting depression and fatigue have demonstrated significant effects. Challenges remain regarding implementation into routine care.
多发性硬化症患者（pwMS）可能特别适合从数字健康应用中获益，因为他们的平均年龄比许多其他慢性病患者更年轻，残疾程度也更低。已经开发了许多针对 pwMS 的数字健康应用。
从患者角度分析数字健康应用改善健康结果的证据。
对所有研究移动健康干预措施（即可以通过智能手机、平板电脑或笔记本电脑应用以改善患者报告的结果）用于多发性硬化症患者的随机对照试验（RCT）进行了系统评价。
在文献检索中确定的 1127 篇文章中，有 13 项 RCT 符合纳入标准。两项试验研究了信息系统，两项研究了抑郁干预，一项研究了多发性硬化症疲劳，五项研究了认知功能，三项研究了移动问题，其中两项集中于痉挛管理。一项试验旨在增强身体活动。大多数是试点研究，不能就疗效得出明确的结论。一项抑郁干预和一项疲劳干预在多个结果上显示出显著效果。
已经在 RCT 中测试了几种针对多发性硬化症患者的移动自我指导数字健康应用，两种针对抑郁和疲劳的干预措施已显示出显著效果。在将其纳入常规护理方面仍然存在挑战。
