Post Graduate Program in Biophotonics Medicine, University Nove de Julho (UNINOVE), Rua Vergueiro, 239/245, São Paulo, SP, 01504-000, Brazil.
Department of Basic Science in Health, Faculty of Medical Sciences, Federal University of Cuiabá, Cuiabá, Brazil.
Lasers Med Sci. 2023 Oct 28;38(1):247. doi: 10.1007/s10103-023-03910-2.
Ulcerative colitis (UC) is a chronic autoimmune disease that impacts the quality of life, but current pharmacological treatments are limited. Photobiomodulation (PBM) is a light-based treatment that can be applied either locally or systemically. Here, we compare the effects of local and vascular PBM (VPBM) in an experimental rat model of UC. Male Wistar rats were induced with UC by rectal instillation of acetic acid and treated with either local abdominal PBM or VPBM to the tail vein using a 660-nm LED. The findings indicated that local PBM but not VPBM reduced intestinal histological scores. Both local and VPBM increased mucus production, decreased mast cell degranulation, and modulated TNF-α and IL-1 β levels in the intestines. Local PBM also affected the expression of the mRNAs for IL-6, TNF-α, and IFN-γ. In conclusion, we suggest that local PBM appears to be more promising than VPBM for treating UC. However, further research is needed to fully understand the mechanisms and to optimize the parameters of PBM for UC treatment.
溃疡性结肠炎（UC）是一种影响生活质量的慢性自身免疫性疾病，但目前的药物治疗有限。光生物调节（PBM）是一种基于光的治疗方法，可以局部或系统应用。在这里，我们比较了局部和血管 PBM（VPBM）在 UC 实验大鼠模型中的效果。雄性 Wistar 大鼠通过直肠内灌注乙酸诱导 UC，并通过 660nm LED 对腹部进行局部 PBM 或尾静脉 VPBM 治疗。结果表明，局部 PBM 而非 VPBM 可降低肠道组织学评分。局部和 VPBM 均增加了黏液的产生，减少了肥大细胞脱颗粒，并调节了肠道中的 TNF-α 和 IL-1β 水平。局部 PBM 还影响了 IL-6、TNF-α 和 IFN-γ 的 mRNA 表达。总之，我们认为局部 PBM 似乎比 VPBM 更有希望治疗 UC。然而，需要进一步研究以充分了解机制，并优化 PBM 治疗 UC 的参数。
