Sagara N, Kurooka K, Mori K, Kayama H, Haeno Y, Hara S, Yasutomi M
Gan To Kagaku Ryoho. 1986 Dec;13(12):3532-4.
Surgery and radiotherapy have been considered to be the primary therapies for malignant thymoma. However, the results of these therapies for invasive thymoma are poor. Recently, combination chemotherapy for invasive thymoma has been tried and good results have been reported. A 50-year-old female was admitted to our hospital. Her chest film showed a large anterior mediastinal tumor which was diagnosed as invasive thymoma. In order to remove the tumor, median sternotomy and 4th intercostal thoracotomy was done but the mass was found to have invaded to the adjacent tissues, and so only partial resection of the tumor was performed. Postoperatively, the patient was treated with Adriamycin, Vindesine and 5-FU, as a result of which the mass completely disappeared and CR was achieved. Our regimen, AVF, for non-resectable thymoma is therefore thought to be a potentially effective treatment.
手术和放疗一直被视为恶性胸腺瘤的主要治疗方法。然而，这些疗法对侵袭性胸腺瘤的效果不佳。最近，有人尝试对侵袭性胸腺瘤进行联合化疗，并报告了良好的效果。一名50岁女性入住我院。她的胸部X光片显示前纵隔有一个大肿瘤，被诊断为侵袭性胸腺瘤。为了切除肿瘤，进行了正中胸骨切开术和第四肋间开胸术，但发现肿块已侵犯相邻组织，因此仅对肿瘤进行了部分切除。术后，患者接受了阿霉素、长春地辛和5-氟尿嘧啶治疗，结果肿块完全消失，达到了完全缓解。因此，我们用于不可切除胸腺瘤的AVF方案被认为是一种潜在有效的治疗方法。
