[一例对卡铂、阿霉素和依托泊苷新辅助化疗有显著反应的晚期侵袭性胸腺瘤]
[An advanced invasive thymoma that responded remarkably to neoadjuvant chemotherapy with carboplatin, adriamycin, and etoposide].
作者信息
Bando S, Ikeda T, Yamanouchi H, Ohnishi T, Yamaji Y, Fujita J, Takahara J, Maeda M
机构信息
First Department of Internal Medicine, Kagawa Medical School.
出版信息
Nihon Kyobu Shikkan Gakkai Zasshi. 1995 Oct;33(10):1135-40.
A 23-year-old man was admitted to the hospital with hoarseness caused by recurrent nerve palsy. The chest X-ray film and CT scan on admission showed a large mass in the antero-superior part of the mediastinum and a small round mediastinal mass adjacent to right inferior pericardium. Examination of a specimen aspirated from the mediastinal mass revealed thymoma. The tumor was considered to be inoperable because of the pericardial dissemination, and the patient was treated with carboplatin, Adriamycin, and etoposide. After 4 courses of chemotherapy, remarkable regression of both tumors was observed on a chest X-ray film. The patient underwent surgery, and no remaining tumor was found. A combination of carboplatin, Adriamycin, and etoposide may be useful as neoadjuvant chemotherapy for advanced invasive thymoma.
一名23岁男性因喉返神经麻痹导致声音嘶哑入院。入院时胸部X线片和CT扫描显示纵隔前上部有一巨大肿块，右下心包旁有一小圆形纵隔肿块。对纵隔肿块穿刺获取的标本进行检查发现为胸腺瘤。由于心包播散，该肿瘤被认为无法手术切除，患者接受了卡铂、阿霉素和依托泊苷治疗。4个疗程的化疗后，胸部X线片显示两个肿瘤均显著缩小。患者接受了手术，未发现残留肿瘤。卡铂、阿霉素和依托泊苷联合应用可能作为晚期侵袭性胸腺瘤的新辅助化疗有效。
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