一种草药漱口水用于治疗牙周炎和放射性口腔黏膜炎的疗效——两项随机对照临床试验的综合报告

Efficacy of a herbal mouthwash for management of periodontitis and radiation-induced mucositis - A consolidated report of two randomized controlled clinical trials.

作者信息

Ambili R, Ramadas K, Nair Lekha M, Raj Divya, Nazeer Farida, George Preethi Sara, Rejnish Kumar R, Radhakrishna Pillai M

机构信息

Department of Periodontics, PMS College of Dental Science and Research, Thiruvananthapuram, India.

Department of Radiation Oncology, Regional Cancer Centre, Thiruvananthapuram, India.

出版信息

J Ayurveda Integr Med. 2023 Nov-Dec;14(6):100791. doi: 10.1016/j.jaim.2023.100791. Epub 2023 Oct 27.

DOI:10.1016/j.jaim.2023.100791

PMID:37897968

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10641263/

Abstract

BACKGROUND

Oral diseases like periodontitis and mucositis often require home care using topical agents in the form of mouthwashes. Many herbal mouthwashes are found to be beneficial; however lack proper scientific evidence to support their use.

OBJECTIVES

Study 1 evaluated clinical efficacy of herbal mouthwash in the management of chronic periodontitis in comparison with chlorhexidine mouthwash. Study 2 aimed at assessment of herbal mouthwash in patients of radiation-induced mucosititis.

METHODS

The novel herbal mouthwash used in the present study wa prepared from extracts of five plants namely Emblica Officinalis, Terminalia chebula, Terminalia bellerica, Glycyrrhiza glabra, and Azadirachta indica. 50 periodontitis patients were randomly allocated to two groups. As per allocation, they were instructed to use either herbal mouthwash or chlorhexidine mouthwash twice daily for two weeks after nonsurgical periodontal therapy. Similarly, patients with radiation-induced mucositis were randomly given herbal mouthwash and soda saline mouthwash. Intergroup and intragroup comparisons of continuous variables were conducted using paired and unpaired t-tests. Categorical variables were compared using the chi-square test.

RESULTS

Significant reductions in gingival bleeding, plaque accumulation, and pocket depth were noticed in periodontitis patients in both groups. Patients reported acceptable taste, freshness, and satisfaction after the use of herbal mouthwash. The herbal mouthwash group noticed a significant reduction in the severity of radiation-induced mucositis and analgesic requirements. The intensity of pain, dryness of mouth, oral hygiene, and need for the use of antibiotic and antifungal during radiotherapy was not significant among the groups.

CONCLUSION

The results of this preliminary clinical trial support the use of the tested herbal formulation mouthwash as an adjunct in the treatment of periodontitis as well as radiation-induced mucositis.

CLINICAL TRIAL REGISTRATION NUMBER

For Study 1: CTRI/2019/10/021574, Study 2: CTRI/2020/04/024851.

摘要

背景

牙周炎和口腔黏膜炎等口腔疾病通常需要使用漱口水形式的局部用药进行家庭护理。许多草药漱口水被发现有益；然而，缺乏适当的科学证据来支持其使用。

目的

研究1评估了草药漱口水与氯己定漱口水相比在慢性牙周炎管理中的临床疗效。研究2旨在评估草药漱口水对放射性口腔黏膜炎患者的效果。

方法

本研究中使用的新型草药漱口水由余甘子、诃子、毛诃子、光果甘草和印楝这五种植物的提取物制成。50名牙周炎患者被随机分为两组。根据分组情况，在非手术牙周治疗后，指示他们每天使用草药漱口水或氯己定漱口水两次，持续两周。同样，放射性口腔黏膜炎患者被随机给予草药漱口水和苏打盐水漱口水。连续变量的组间和组内比较采用配对和非配对t检验。分类变量采用卡方检验进行比较。