Department of Dental Hygiene, Jeonju Kijeon College, Jeonju 54989, Republic of Korea.
Department of Oral and Maxillofacial Surgery, School of Dentistry and Institute of Oral Bioscience, Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonbuk National University, Jeonju 54907, Republic of Korea.
Photodiagnosis Photodyn Ther. 2024 Feb;45:103867. doi: 10.1016/j.pdpdt.2023.103867. Epub 2023 Oct 26.
Medication-related osteonecrosis of the jaw (MRONJ) is a challenging condition with increasing incidence, and the lack of clear surgical guidelines poses difficulties in its treatment.
Quantitative light-induced fluorescence (QLF), which can distinguish between vital and necrotic bone tissue without the need for additional markers, was used to guide minimally invasive surgery in a 75-year-old patient with MRONJ.
This study demonstrated that QLF allows the real-time identification of infected and necrotic bone tissue during surgery, enabling precise and minimally invasive resection. We observed spontaneous bone recovery and remodeling in sclerotic bone areas that exhibited autofluorescence using a QLF device, suggesting its potential for preserving the bone tissue.
This study highlights the promising application of QLF as a valuable photodiagnostic tool in MRONJ surgery, offering a noninvasive and intraoperative device for differentiating pathological bone tissue. This approach can potentially improve the precision of surgical interventions and contribute to improved patient outcomes in MRONJ management.
药物相关性下颌骨坏死（MRONJ）是一种发病率不断增加的具有挑战性的疾病，由于缺乏明确的手术指南，其治疗存在困难。
定量光致荧光（QLF）可在无需额外标记的情况下区分活骨组织和坏死骨组织，本研究采用 QLF 引导一位 75 岁的 MRONJ 患者行微创手术。
本研究表明，QLF 可在手术过程中实时识别感染和坏死的骨组织，实现精确和微创切除。我们观察到在使用 QLF 设备时，硬化骨区域的自发性骨恢复和重塑呈现自发荧光，这表明 QLF 具有保留骨组织的潜力。
本研究强调了 QLF 作为 MRONJ 手术中一种有前途的光诊断工具的应用，为区分病理性骨组织提供了一种非侵入性和术中的设备。这种方法可能会提高手术干预的准确性，并有助于改善 MRONJ 管理的患者预后。
