饮食中链脂肪酸与以低收入人群为主的结直肠癌发病风险：来自南方社区队列研究的报告。
Dietary medium-chain fatty acids and risk of incident colorectal cancer in a predominantly low-income population: a report from the Southern Community Cohort Study.
机构信息
Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, United States.
Department of Biostatistics, Vanderbilt University, Nashville, TN, United States.
出版信息
Am J Clin Nutr. 2024 Jan;119(1):7-17. doi: 10.1016/j.ajcnut.2023.10.024. Epub 2023 Oct 26.
BACKGROUND
No prospective observational study has specifically examined the associations between dietary intakes of medium-chain fatty acids and risk of colorectal cancer.
OBJECTIVES
This study examined the association between dietary intakes of medium-chain fatty acids and colorectal cancer risk overall and by racial subgroups in a predominantly low-income United States population.
METHODS
This prospective study included 71,599 eligible participants aged 40 to 79 who were enrolled in the Southern Community Cohort Study between 2002 and 2009 in 12 southeastern United States states. Incident colorectal cancer cases were ascertained via linkage to state cancer registries, which was completed through 31 December, 2016. The dietary intakes of medium-chain fatty acids were assessed using a validated 89-item food frequency questionnaire. Multivariable Cox proportional hazards regression models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations between intakes of medium-chain fatty acids and risk for incident colorectal cancer.
RESULTS
Among 71,599 participants, 48,008 (67.3%) were Black individuals and 42,260 (59.0%) were female. A total of 868 incident colorectal cancer cases occurred during a median follow-up of 13.7 y. Comparing the highest to the lowest quartile, high intake of dodecanoic acid/lauric acid (C12:0) was associated with reduced risk of colorectal cancer among White participants (HR: 0.52; 95% CI: 0.30, 0.91; P-trend = 0.05), but not in Black individuals (HR: 0.92; 95% CI, 0.68, 1.24; P-trend = 0.80) in multivariable-adjusted models. No associations were found between intakes of hexanoic acid/caproic acid (C6:0), octanoic acid/caprylic acid (C8:0), or decanoic acid/capric acid (C10:0) and risk of incident colorectal cancer overall or within racial subgroups.
CONCLUSIONS
In a predominantly low-income United States population, an increased dietary C12:0 intake was associated with a substantially reduced risk of colorectal cancer only among White individuals, but not in Black individuals.
背景
尚无前瞻性观察研究专门探讨中链脂肪酸的饮食摄入量与结直肠癌风险之间的关系。
目的
本研究在美国以低社会经济地位为主的人群中，按种族亚组分析中链脂肪酸的饮食摄入量与结直肠癌风险之间的总体关联。
方法
这项前瞻性研究纳入了 2002 年至 2009 年间在美国东南部 12 个州参加南方社区队列研究的 71599 名年龄在 40 岁至 79 岁之间的合格参与者。通过与州癌症登记处的链接确定结直肠癌病例，链接完成于 2016 年 12 月 31 日。使用经过验证的 89 项食物频率问卷评估中链脂肪酸的饮食摄入量。多变量 Cox 比例风险回归模型用于计算中链脂肪酸摄入量与结直肠癌发病风险之间的关联的风险比（HR）和 95%置信区间（CI）。
结果
在 71599 名参与者中，48008 名（67.3%）为黑人，42260 名（59.0%）为女性。中位随访 13.7 年后共发生 868 例结直肠癌病例。与最低四分位相比，高摄入量的十二烷酸/月桂酸（C12：0）与白人参与者结直肠癌风险降低相关（HR：0.52；95%CI：0.30，0.91；P 趋势=0.05），但在黑人参与者中则无关联（HR：0.92；95%CI：0.68，1.24；P 趋势=0.80）。在多变量调整模型中，未发现己酸/辛酸（C6：0）、辛酸/癸酸（C8：0）或癸酸/月桂酸（C10：0）的摄入量与结直肠癌发病风险之间存在总体或按种族亚组的关联。
结论
在以低社会经济地位为主的美国人群中，中链脂肪酸 C12：0 的饮食摄入量增加与白人个体结直肠癌风险显著降低相关，但与黑人个体无关。
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