Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, Tasmania, Australia
Biomedical Sciences Department (Medical Physiology Unit), College of Medicine and Health Science, Debre Tabor University, Debre Tabor, Ethiopia.
BMJ Open. 2023 Oct 28;13(10):e076005. doi: 10.1136/bmjopen-2023-076005.
Evidence suggests that the pathology underlying cognitive decline leading to dementia begins 15-20 years before cognitive symptoms emerge. Thus, identifying biomarkers in this preclinical phase is critically important. Age-related decrease in muscle mass and strength, a known risk factor for sarcopenia, frailty and cognitive decline, also affects the tongue. This paper describes an a priori protocol by a multidisciplinary team to address the following questions relating to adults ≥50 years of age: (1) What is the current evidence on the association of tongue strength with cognitive decline? (2) How does tongue strength associate with frailty and sarcopenia? (3) What is the association of tongue strength with nutritional health?
Search terms will be identified then multiple electronic databases (PubMed, PsycINFO (Ovid), Scopus, Embase (Ovid), CINAHL and Web of Science) searched systematically for peer-reviewed articles published in English that address the following inclusion criteria: (1) human studies, (2) participants ≥50 years of age and (3) studies with tongue pressure values measured in relation to at least one of the following: frailty, sarcopenia, nutritional health, cognitive function and dementia (Alzheimer's, vascular, frontotemporal and Lewy body). Grey literature also will be searched to identify additional studies, clinical trials and policy papers appropriate for inclusion. The search will be from database inception. After removing duplicates, two research team members will independently screen abstracts and identify articles for full-text review. The team will use a data charting tool for data extraction. Data will be analysed quantitatively and qualitatively.
The scoping review does not require ethics approval as data will be from publicly available sources. Results will be disseminated in workshops and conferences and a peer-reviewed journal paper.
有证据表明，导致痴呆的认知能力下降的潜在病理学在认知症状出现前 15-20 年就开始了。因此，在临床前阶段识别生物标志物至关重要。与年龄相关的肌肉质量和力量下降是肌肉减少症、虚弱和认知能力下降的已知风险因素，也会影响舌头。本文描述了一个多学科团队的预先方案，旨在解决以下与 50 岁以上成年人相关的问题：（1）目前关于舌力与认知能力下降之间关联的证据是什么？（2）舌力与虚弱和肌肉减少症有何关联？（3）舌力与营养健康的关联是什么？
将确定检索词，然后系统地在多个电子数据库（PubMed、PsycINFO（Ovid）、Scopus、Embase（Ovid）、CINAHL 和 Web of Science）中搜索以英语发表的同行评议文章，这些文章符合以下纳入标准：（1）人类研究，（2）参与者年龄≥50 岁，（3）研究使用舌压值与以下至少一项相关：虚弱、肌肉减少症、营养健康、认知功能和痴呆（阿尔茨海默病、血管性、额颞叶和路易体）。还将搜索灰色文献以确定其他适合纳入的研究、临床试验和政策文件。搜索将从数据库建立开始。去除重复项后，两名研究团队成员将独立筛选摘要并确定全文审查的文章。团队将使用数据图表工具进行数据提取。数据将进行定量和定性分析。
该范围综述不需要伦理批准，因为数据将来自公开来源。结果将在研讨会和会议以及同行评议的期刊论文中进行传播。
