Colacchio T A, Memoli V A
Arch Surg. 1986 Dec;121(12):1421-4. doi: 10.1001/archsurg.1986.01400120071012.
The organospecific, 1,2-dimethylhydrazine-induced rat tumor model was used to test tumor formation in groups of animals receiving regular chow, powdered chow with 7%/wt ascorbic acid supplement, pelleted chow with 1%/wt beta-carotene supplement, and pelleted chow with placebo beadlets. Following a 16-week induction period, animals were killed and tumor formation was recorded. Tumor formation in the ascorbic acid supplement group was found to be significantly less than the control group. The beta-carotene group showed no difference in tumor formation compared with the placebo-beadlet control group. Tumor incidence was generally the same between the two control groups, and the ascorbic acid group had significantly fewer tumors than the beta-carotene group. In sum, ascorbic acid supplements in high doses significantly decreased tumor formation, whereas beta-carotene supplements in moderately high doses had no effect on tumor formation in this model.
采用器官特异性的1,2 - 二甲基肼诱导大鼠肿瘤模型，对接受普通饲料、添加7%（重量）抗坏血酸的粉状饲料、添加1%（重量）β - 胡萝卜素的颗粒饲料以及添加安慰剂小丸的颗粒饲料的动物组进行肿瘤形成测试。经过16周的诱导期后，处死动物并记录肿瘤形成情况。发现抗坏血酸补充剂组的肿瘤形成明显少于对照组。β - 胡萝卜素组与安慰剂小丸对照组相比，肿瘤形成无差异。两个对照组的肿瘤发生率总体相同，且抗坏血酸组的肿瘤明显少于β - 胡萝卜素组。总之，高剂量的抗坏血酸补充剂显著降低了肿瘤形成，而中等高剂量的β - 胡萝卜素补充剂对该模型中的肿瘤形成没有影响。
