一般日本人群的生活满意度与动脉粥样硬化性心血管疾病风险：Suita 研究。
Life satisfaction and the risk of atherosclerotic cardiovascular disease in the general Japanese population: the Suita Study.
机构信息
Department of Preventive Cardiology, National Cerebral and Cardiovascular Center.
Department of Public Health, Faculty of Medicine, Beni-Suef University.
出版信息
Environ Health Prev Med. 2023;28:62. doi: 10.1265/ehpm.23-00125.
BACKGROUND
Atherosclerotic cardiovascular disease (ASCVD) is a major cause of morbidity and mortality. Life satisfaction is a measure of mental health with a potential cardioprotective role. This study aimed to investigate the association between life satisfaction and ASCVD risk in the general Japanese population.
METHOD
We used data from 6,877 people (30-84 years) registered in the Suita Study, a Japanese population-based prospective cohort study. All participants were free from stroke and coronary heart disease (CHD) at baseline. Then, participants were followed up for incident ASCVD, including cerebral infarction and CHD. Cox proportional hazards models were used to calculate the hazard ratio (HR) and 95% confidence interval (95% CI) of incident ASCVD according to life satisfaction.
RESULTS
Within 102,545 person-years (median follow-up = 16.6 years), 482 incident ASCVD events were identified. In the age- and sex-adjusted model, being very satisfied, rather satisfied, or not sure, compared to being dissatisfied with life, showed a lower risk of ASCVD: HR (95% CI) = 0.55 (0.41, 0.74), 0.67 (0.50, 0.89), and 0.57 (0.36, 0.88), respectively (p-trend < 0.001). The associations remained consistent after adjusting for stress and unfortunate events: HR (95% CI) = 0.57 (0.42, 0.77), 0.68 (0.50, 0.91), and 0.54 (0.35, 0.84), respectively (p-trend < 0.001). The results did not vary between cerebral infarction and CHD: HR (95% CI) for being very satisfied with life = 0.58 (0.37, 0.91) and 0.55 (0.36, 0.84), respectively.
CONCLUSION
Life satisfaction was inversely associated with the risk of ASCVD in the investigated general Japanese population.
背景
动脉粥样硬化性心血管疾病（ASCVD）是发病率和死亡率的主要原因。生活满意度是衡量心理健康的一个指标，可能具有心脏保护作用。本研究旨在调查日本普通人群的生活满意度与 ASCVD 风险之间的关系。
方法
我们使用了来自 Suita 研究的 6877 名（30-84 岁）参与者的数据，该研究是一项基于日本人群的前瞻性队列研究。所有参与者在基线时均无中风和冠心病（CHD）。然后，根据生活满意度对参与者进行 ASCVD 事件（包括脑梗死和 CHD）的随访。使用 Cox 比例风险模型计算 ASCVD 事件的风险比（HR）和 95%置信区间（95%CI）。
结果
在 102545 人年（中位随访时间=16.6 年）期间，共发生 482 例 ASCVD 事件。在年龄和性别调整模型中，与对生活不满意相比，非常满意、满意或不确定的人群发生 ASCVD 的风险较低：HR（95%CI）分别为 0.55（0.41，0.74）、0.67（0.50，0.89）和 0.57（0.36，0.88）（趋势检验<0.001）。调整压力和不幸事件后，关联仍然一致：HR（95%CI）分别为 0.57（0.42，0.77）、0.68（0.50，0.91）和 0.54（0.35，0.84）（趋势检验<0.001）。结果在脑梗死和冠心病之间没有差异：生活非常满意的 HR（95%CI）分别为 0.58（0.37，0.91）和 0.55（0.36，0.84）。
结论
在研究的日本普通人群中，生活满意度与 ASCVD 风险呈负相关。
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