Department of Ophthalmology and Visual Science, Hospital Universiti Sains Malaysia, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia.
Department of Pediatrics, Hospital Universiti Sains Malaysia, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia.
Korean J Ophthalmol. 2023 Dec;37(6):462-467. doi: 10.3341/kjo.2023.0040. Epub 2023 Oct 25.
The aim of this study is to determine the mean central corneal thickness (CCT) and mean intraocular pressure (IOP) in children with type 1 diabetes mellitus (T1DM) and to determine the relationship between CCT and IOP on the one hand and age, sex, retinopathy hemoglobin A1c (HbA1c), and duration of diabetes on the other.
This is a case-control, hospital-based study conducted at Hospital Universiti Sains Malaysia between January and November 2022. Thirty-eight children with T1DM were recruited as cases, and 38 healthy children were recruited as controls. The cases and controls then underwent ophthalmic examination, IOP measurement, and CCT measurement using optical coherence tomography (OCT) of the right eye. The IOP measurements were adjusted for CCT for further analysis.
The means of CCT and IOP values were significantly higher in the T1DM group than in the control group (all p = 0.02). The mean CCT was 542.18 ± 20.40 μm in the T1DM group, and 529.52 ± 26.17 μm in the control group. The mean IOP was 14.68 ± 1.98 mmHg in the T1DM group, and 13.52 ± 1.66 mmHg in the control group. The mean HbA1c was 10.68% ± 2.49% in the T1DM group. Age and duration of DM were found to have a significant association with CCT in children with T1DM. The duration of DM was also found to be significantly associated with the IOP. Sex and HbA1c levels were found to have no significant relationship with either CCT or IOP.
Children with T1DM have significantly higher CCT and IOP than the average child. The duration of DM is a significant factor that impacts both CCT and IOP. In addition, age is another factor that affects CCT in children with T1DM.
本研究旨在确定 1 型糖尿病（T1DM）患儿的平均中央角膜厚度（CCT）和平均眼内压（IOP），并确定 CCT 和 IOP 与年龄、性别、视网膜病变糖化血红蛋白（HbA1c）和糖尿病病程之间的关系。
这是一项 2022 年 1 月至 11 月在马来西亚大学医院进行的病例对照、基于医院的研究。招募了 38 名 T1DM 患儿作为病例，招募了 38 名健康儿童作为对照。然后对病例和对照进行眼科检查、IOP 测量和右眼光学相干断层扫描（OCT）测量 CCT。为了进一步分析，对 IOP 测量值进行了 CCT 调整。
T1DM 组的 CCT 和 IOP 值均值明显高于对照组（均 p = 0.02）。T1DM 组的平均 CCT 为 542.18 ± 20.40 μm，对照组为 529.52 ± 26.17 μm。T1DM 组的平均 IOP 为 14.68 ± 1.98 mmHg，对照组为 13.52 ± 1.66 mmHg。T1DM 组的平均 HbA1c 为 10.68%±2.49%。在 T1DM 患儿中，年龄和糖尿病病程与 CCT 有显著相关性。糖尿病病程也与 IOP 显著相关。性别和 HbA1c 水平与 CCT 或 IOP 均无显著关系。
T1DM 患儿的 CCT 和 IOP 明显高于一般儿童。糖尿病病程是影响 CCT 和 IOP 的重要因素。此外，年龄是影响 T1DM 患儿 CCT 的另一个因素。
