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去分化型子宫内膜癌转移至腋窝淋巴结：一例报告。

Dedifferentiated endometrial carcinoma metastasis to axillary lymph node: a case report.

机构信息

Wayne State University, Detroit, USA.

Department of Surgery, Henry Ford Health and Wayne State University Medical School, 2799 W Grand Boulevard, Detroit, MI, 48202, USA.

出版信息

J Med Case Rep. 2023 Oct 30;17(1):451. doi: 10.1186/s13256-023-04192-6.

DOI:10.1186/s13256-023-04192-6
PMID:37899461
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10614416/
Abstract

BACKGROUND: We present an unusual case of a left axillary lymph node metastasis from a primary dedifferentiated endometrial carcinoma. This pattern of metastasis is likely the result of circulating tumor cells reaching the node through its arterial blood supply. CASE PRESENTATION: In this report, a 68-year-old white woman with a dedifferentiated endometrial carcinoma underwent a hysterectomy. She later developed an enlarged axillary lymph node due to metastatic dedifferentiated endometrial carcinoma, treated with chemotherapy and anti-programmed cell death protein 1 immunotherapy resulting in a complete clinical and radiological response. CONCLUSION: A review of the literature reveals the rarity of blood-borne lymph node metastasis, especially with uterine carcinoma. Immunotherapy has shown promising results in the treatment of some subtypes of metastatic uterine carcinoma.

摘要

背景：我们报告了一例罕见的左侧腋窝淋巴结转移性腺分解型子宫内膜癌病例。这种转移模式可能是循环肿瘤细胞通过其动脉血液供应到达淋巴结的结果。

病例介绍：本报告介绍了一例 68 岁白人女性，患有去分化型子宫内膜癌，行子宫切除术。后来，由于转移性去分化型子宫内膜癌，她的腋窝淋巴结肿大，接受化疗和抗程序性细胞死亡蛋白 1 免疫治疗后，完全缓解了临床和影像学表现。

结论：文献回顾表明，血源性淋巴结转移，特别是子宫癌，非常罕见。免疫疗法已显示出在治疗某些亚型转移性子宫癌方面的良好效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/10614416/00578d2976bf/13256_2023_4192_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/10614416/b17af708cb9e/13256_2023_4192_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/10614416/0da9801987b1/13256_2023_4192_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/10614416/3e1e6ed1b9bc/13256_2023_4192_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/10614416/bb9ef021de50/13256_2023_4192_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/10614416/5d1b49b5e063/13256_2023_4192_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/10614416/00578d2976bf/13256_2023_4192_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/10614416/b17af708cb9e/13256_2023_4192_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/10614416/0da9801987b1/13256_2023_4192_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/10614416/3e1e6ed1b9bc/13256_2023_4192_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/10614416/bb9ef021de50/13256_2023_4192_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/10614416/5d1b49b5e063/13256_2023_4192_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eac7/10614416/00578d2976bf/13256_2023_4192_Fig6_HTML.jpg

相似文献

[1]
Dedifferentiated endometrial carcinoma metastasis to axillary lymph node: a case report.

J Med Case Rep. 2023-10-30

[2]
Accuracy of Sentinel Node in Detecting Lymph Node Metastasis in Primary Endometrial Carcinoma.

Asian Pac J Cancer Prev. 2015

[3]
Long-term survival in patients with para-aortic lymph node metastasis with systematic retroperitoneal lymphadenectomy followed by adjuvant chemotherapy in endometrial carcinoma.

Int J Gynecol Cancer. 2010-8

[4]
Axillary mass suspected to be occult breast carcinoma: a case study of skipped axillary lymph node metastasis from endometrial carcinoma in which core-needle biopsy was useful for diagnosis.

Breast Cancer. 2009

[5]
[Metastatic mechanisms of uterine malignancies and therapeutic consequences].

Pathologe. 2016-11

[6]
Undifferentiated component of dedifferentiated endometrial carcinoma presenting as a "small round cell" malignancy in a mediastinal lymph node, mimicking small cell carcinoma.

Diagn Cytopathol. 2023-8

[7]
Lower uterine segment involvement in lymphovascular space invasion and lymph node metastasis in endometrioid endometrial cancer.

Ginekol Pol. 2019

[8]
A retrospective analysis of the diameter of metastatic lymph nodes in apparently early stage endometrial cancer.

Tumori. 2008

[9]
Idiopathic retroperitoneal fibrosis with endometrial cancer: a case report and literature review.

BMC Womens Health. 2022-10-1

[10]
Sentinel lymph nodes (SLN) in endometrial cancer: The relationship between primary tumor histology, SLN metastasis size, and non-sentinel node metastasis.

Gynecol Oncol. 2019-4-23

引用本文的文献

[1]
XGBoost-based nomogram for predicting lymph node metastasis in endometrial carcinoma.

Am J Cancer Res. 2024-12-15

本文引用的文献

[1]
Role of Sentinel Lymph Node Biopsy for Skin Cancer Based on Clinical Studies.

Cancers (Basel). 2023-6-22

[2]
Left Axilla Adenocarcinoma of Unknown Origin.

JAMA Oncol. 2023-5-1

[3]
Factor affecting lymph node metastasis in uterine papillary serous carcinomas: a retrospective analysis.

J Obstet Gynaecol. 2022-11

[4]
Biomarker-driven therapy in endometrial cancer.

Int J Gynecol Cancer. 2023-3-6

[5]
Breast metastasis from endometrial clear cell carcinoma: A case report and review of the literature.

Front Oncol. 2023-1-25

[6]
Rare metastasis of gastric cancer to the axillary lymph node: A case report.

Front Oncol. 2022-10-25

[7]
Rare Subtype of Endometrial Cancer: Undifferentiated/Dedifferentiated Endometrial Carcinoma, from Genetic Aspects to Clinical Practice.

Int J Mol Sci. 2022-3-30

[8]
Left supraclavicular (Virchow's) node metastasis detected before primary infradiaphragmatic tumor: a case series.

J Med Case Rep. 2022-1-26

[9]
Pembrolizumab in Patients With Microsatellite Instability-High Advanced Endometrial Cancer: Results From the KEYNOTE-158 Study.

J Clin Oncol. 2022-3-1

[10]
Phase 3, randomized, open-label study of pembrolizumab plus lenvatinib versus chemotherapy for first-line treatment of advanced or recurrent endometrial cancer: ENGOT-en9/LEAP-001.

Int J Gynecol Cancer. 2022-1

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