Sakyi Samuel A, Tawiah Phyllis, Senu Ebenezer, Ampofo Ransford O, Enimil Anthony K, Amoani Benjamin, Anto Enoch O, Opoku Stephen, Effah Alfred, Abban Elizabeth, Frimpong Joseph, Frimpong Emmaunel, Bannor Lydia Oppong, Kwayie Afia A, Naturinda Emmanuel, Ansah Eugene A, Baidoo Bright T, Kodzo Kini E, Ayisi-Boateng Nana K
Department of Molecular Medicine Kwame Nkrumah University of Science and Technology Kumasi Ghana.
Department of Medicine, School of Medicine and Dentistry Kwame Nkrumah University of Science and Technology Kumasi Ghana.
Health Sci Rep. 2023 Oct 25;6(10):e1664. doi: 10.1002/hsr2.1664. eCollection 2023 Oct.
Frailty is a condition marked by accumulation of biological deficits and dysfunctions that come with aging and it is correlated with high morbidity and mortality in patients with cardiovascular diseases, particularly hypertension. Hypertension continues to be a leading cause of cardiovascular diseases and premature death globally. However, there is dearth of literature in sub-Saharan Africa on frailty syndrome among hypertensives on medication. This study evaluated frailty syndrome and its associated factors among Ghanaian hypertensives.
This cross-sectional study recruited 303 patients with hypertension from the University Hospital, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana. Data on sociodemographic, lifestyle and clinical factors were collected using a well-structured questionnaire. Medication adherence was measured using Adherence in Chronic Disease Scale, and frailty was assessed by Tilburg Frailty Indicator. Statistical analyses were performed using SPSS Version 26.0 and GraphPad prism 8.0. value of < 0.05 and 95% confidence interval (CI) were considered statistically significant.
The prevalence of frailty was 59.7%. The proportion of high, medium and low medication adherence was 23.4%, 64.4% and 12.2%, respectively. Being ≥ 70years (adjusted odds ratio [aOR]: 8.33, 95% CI [3.72-18.67], < 0.0001), unmarried (aOR: 2.59, 95% CI [1.37-4.89], = 0.0030), having confirmed hypertension complications (aOR: 3.21, 95% CI [1.36-7.53], = 0.0080), medium (aOR: 1.99, 95% CI [1.05-3.82], = 0.0360) and low antihypertensive drug adherence (aOR: 27.69, 95% CI [7.05-108.69], < 0.0001) were independent predictors of increased odds of developing frailty syndrome.
Approximately 6 out of 10 Ghanaian adult patients with hypertension experience frailty syndrome. Hypertension complications, older age, being unmarried, and low antihypertensive drug adherence increased the chances of developing frailty syndrome. These should be considered in intervention programmes to prevent frailty among patients with hypertension.
衰弱是一种因衰老导致生物缺陷和功能障碍积累而出现的状况，与心血管疾病患者，尤其是高血压患者的高发病率和高死亡率相关。高血压仍然是全球心血管疾病和过早死亡的主要原因。然而，撒哈拉以南非洲地区关于正在接受药物治疗的高血压患者衰弱综合征的文献匮乏。本研究评估了加纳高血压患者的衰弱综合征及其相关因素。
这项横断面研究从加纳库马西夸梅·恩克鲁玛科技大学（KNUST）大学医院招募了303名高血压患者。使用结构完善的问卷收集社会人口学、生活方式和临床因素的数据。使用慢性病依从性量表测量药物依从性，并用蒂尔堡衰弱指标评估衰弱情况。使用SPSS 26.0版和GraphPad prism 8.0进行统计分析。P值<0.05和95%置信区间（CI）被认为具有统计学意义。
衰弱的患病率为59.7%。高、中、低药物依从性的比例分别为23.4%、64.4%和12.2%。年龄≥70岁（调整后的优势比[aOR]：8.33，95%CI[3.72 - 18.67]，P<0.0001）、未婚（aOR：2.59，95%CI[1.37 - 4.89]，P = 0.0030）、已确诊高血压并发症（aOR：3.21，95%CI[1.36 - 7.53]，P = 0.0080）、中等（aOR：1.99，95%CI[1.05 -
