Editorial: Mechanisms of early intracellular signaling in T lymphocytes.
作者信息
Aguado Enrique, Arbulo-Echevarria Mikel M, Compeer Ewoud B
机构信息
Institute of Biomedical Research Cadiz (INIBICA), Cádiz, Spain.
Department of Biomedicine, Biotechnology and Public Health (Immunology), University of Cádiz, Cádiz, Spain.
出版信息
Front Immunol. 2025 Jun 17;16:1638330. doi: 10.3389/fimmu.2025.1638330. eCollection 2025.
Abstract
摘要
相似文献
1
Editorial: Mechanisms of early intracellular signaling in T lymphocytes.社论：T淋巴细胞早期细胞内信号传导机制
Front Immunol. 2025 Jun 17;16:1638330. doi: 10.3389/fimmu.2025.1638330. eCollection 2025.
2
MyD88 determines T cell fate through BCAP-PI3K signaling.髓样分化因子88（MyD88）通过BCAP-磷脂酰肌醇-3激酶（PI3K）信号通路决定T细胞命运。
J Immunol. 2025 Feb 23;214(3):433-45. doi: 10.1093/jimmun/vkae037.
3
SAP-mediated inhibition of diacylglycerol kinase α regulates TCR-induced diacylglycerol signaling.SAP 通过抑制二酰基甘油激酶 α 调节 TCR 诱导的二酰基甘油信号转导。
J Immunol. 2011 Dec 1;187(11):5941-51. doi: 10.4049/jimmunol.1002476. Epub 2011 Nov 2.
4
Impaired thymic selection in mice expressing altered levels of the SLP-76 adaptor protein.表达改变水平的接头蛋白SLP-76的小鼠中胸腺选择受损。
J Leukoc Biol. 2008 Feb;83(2):419-29. doi: 10.1189/jlb.0507297. Epub 2007 Oct 26.
5
The Role of Adaptor Proteins in the Biology of Natural Killer T (NKT) Cells.衔接蛋白在自然杀伤 T（NKT）细胞生物学中的作用。
Front Immunol. 2019 Jun 25;10:1449. doi: 10.3389/fimmu.2019.01449. eCollection 2019.
6
Cortical Thymic Epithelial Cells: Key Developers of the Code of T-Cell Selection and TCR Repertoire Diversity.皮质胸腺上皮细胞：T细胞选择编码和TCR库多样性的关键开发者。
Immunol Rev. 2025 Jul;332(1):e70049. doi: 10.1111/imr.70049.
7
Next-Generation CAR-T and TCR-T Cell Therapies for Solid Tumors: Innovations, Challenges, and Global Development Trends.用于实体瘤的下一代嵌合抗原受体T细胞（CAR-T）和T细胞受体T细胞（TCR-T）疗法：创新、挑战与全球发展趋势
Cancers (Basel). 2025 Jun 11;17(12):1945. doi: 10.3390/cancers17121945.
8
Expression of Non-T Cell Activation Linker (NTAL) in Jurkat Cells Negatively Regulates TCR Signaling: Potential Role in Rheumatoid Arthritis.NTAL 在 Jurkat 细胞中的表达负调控 TCR 信号：在类风湿关节炎中的潜在作用。
Int J Mol Sci. 2023 Feb 26;24(5):4574. doi: 10.3390/ijms24054574.
9
T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane.T细胞受体（TCR）相互作用分子（TRIM）是一种与TCR-CD3-ζ复合物相关的新型二硫键连接的二聚体，它将细胞内信号蛋白募集到质膜上。
J Exp Med. 1998 Aug 3;188(3):561-75. doi: 10.1084/jem.188.3.561.
10
Efficacy and safety of third-generation CD19-CAR T cells incorporating CD28 and TLR2 intracellular domains for B-cell malignancies with central nervous system involvement: results of a pivotal trial.纳入CD28和TLR2细胞内结构域的第三代CD19嵌合抗原受体T细胞治疗合并中枢神经系统受累的B细胞恶性肿瘤的疗效和安全性：一项关键试验的结果
J Transl Med. 2025 May 27;23(1):594. doi: 10.1186/s12967-025-06608-x.
本文引用的文献
1
Recent advances in understanding TCR signaling: a synaptic perspective.TCR信号传导理解的最新进展：从突触角度看
Fac Rev. 2023 Oct 16;12:25. doi: 10.12703/r/12-25. eCollection 2023.
2
A Story of Kinases and Adaptors: The Role of Lck, ZAP-70 and LAT in Switch Panel Governing T-Cell Development and Activation.激酶与接头蛋白的故事：Lck、ZAP-70和LAT在调控T细胞发育与激活的开关面板中的作用
Biology (Basel). 2023 Aug 24;12(9):1163. doi: 10.3390/biology12091163.
3
A single-amino acid substitution in the adaptor LAT accelerates TCR proofreading kinetics and alters T-cell selection, maintenance and function.一个位于衔接蛋白 LAT 上的单一氨基酸取代可加速 TCR 校对动力学，并改变 T 细胞的选择、维持和功能。
Nat Immunol. 2023 Apr;24(4):676-689. doi: 10.1038/s41590-023-01444-x. Epub 2023 Mar 13.
4
Clathrin mediates both internalization and vesicular release of triggered T cell receptor at the immunological synapse.网格蛋白介导触发型 T 细胞受体在免疫突触处的内化和小泡释放。
Proc Natl Acad Sci U S A. 2023 Feb 7;120(6):e2211368120. doi: 10.1073/pnas.2211368120. Epub 2023 Feb 2.
5
Mutation of the glycine residue preceding the sixth tyrosine of the LAT adaptor severely alters T cell development and activation.LAT 衔接蛋白第六个酪氨酸前的甘氨酸残基发生突变会严重改变 T 细胞的发育和激活。
Front Immunol. 2022 Dec 7;13:1054920. doi: 10.3389/fimmu.2022.1054920. eCollection 2022.
6
A mobile endocytic network connects clathrin-independent receptor endocytosis to recycling and promotes T cell activation.一个移动的胞吞网络将网格蛋白非依赖型受体胞吞作用与循环连接起来，并促进 T 细胞激活。
Nat Commun. 2018 Apr 23;9(1):1597. doi: 10.1038/s41467-018-04088-w.
Zotero 插件