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1型糖尿病患者的韦伦综合征变体:一例报告。

Variant of Wellen's syndrome in type 1 diabetic patient: A case report.

作者信息

Obi Mukosolu Florence, Sharma Manjari, Namireddy Vikhyath, Gargiulo Paul, Noel Chelsea, Hyun Cho, Gale Blossom De

机构信息

Internal Medicine, Wyckoff Heights Medical Center, Brooklyn, NY 11237, United States.

Clinical Rotations, St Georges University, School of Medicine, True Blue 96038, Grenada.

出版信息

World J Cardiol. 2023 Sep 26;15(9):462-468. doi: 10.4330/wjc.v15.i9.462.

Abstract

BACKGROUND

Wellen's syndrome is a form of acute coronary syndrome associated with proximal left anterior descending artery (LAD) stenosis and characteristic electrocardiograph (ECG) patterns in pain free state. The abnormal ECG pattern is classified into type A (biphasic T waves) and type B (deeply inverted T waves), based on the T wave pattern seen in the pericodial chest leads.

CASE SUMMARY

We present the case of a 37-year-old male with history of type 1 diabetes mellitus (T1DM), gastroparesis, mild peripheral artery disease and right toe cellulitis on IV antibiotics who presented to the emergency department with nausea, vomiting and abdominal pain for 3 d and as a result couldn't take his insulin. Noted to have fasting blood sugar 392 mg/dL. Admitted for diabetic gastroparesis. During the hospital course, the patient was asymptomatic and denied any chest pain. On admission, No ECG and troponin draws were performed. On day 2, the patient became hypoxic with oxygen saturation 80% on room air, intermittent mild right-sided chest pain which he attributed to vomiting from his gastroparesis. Initial ECG done was significant for Biphasic T wave changes in leads V2 and V3 and elevated high sensitivity troponin. Patient was transitioned to cardiac intensive care unit and cardiac catheterization performed with result significant for extensive coronary artery disease.

CONCLUSION

This case highlights an exceptional manifestation of Wellen's syndrome, wherein the right coronary artery and circumflex artery display a remarkable 100% constriction, alongside a proximal LAD stenosis of 90%-95%. Notably, this occurrence transpired in a patient grappling with extensive complications arising from T1DM. Moreover, it underscores the utmost significance of promptly recognizing the presence of Wellen's syndrome and swiftly initiating appropriate medical intervention.

摘要

背景

韦伦综合征是急性冠状动脉综合征的一种形式,与左前降支近端狭窄及无痛状态下的特征性心电图模式相关。根据胸前导联的T波形态,异常心电图模式分为A型(双向T波)和B型(深倒置T波)。

病例摘要

我们报告一例37岁男性患者,有1型糖尿病(T1DM)、胃轻瘫、轻度外周动脉疾病病史,因右脚趾蜂窝织炎正在接受静脉抗生素治疗,因恶心、呕吐和腹痛3天就诊于急诊科,因此未服用胰岛素。空腹血糖为392mg/dL。因糖尿病胃轻瘫入院。在住院期间,患者无症状,否认有任何胸痛。入院时未进行心电图和肌钙蛋白检查。第2天,患者出现低氧血症,在室内空气中氧饱和度为80%,有间歇性轻度右侧胸痛,他认为是胃轻瘫引起的呕吐所致。最初的心电图显示V2和V3导联有双向T波改变,高敏肌钙蛋白升高。患者被转入心脏重症监护病房并进行了心脏导管检查,结果显示有广泛的冠状动脉疾病。

结论

本病例突出了韦伦综合征的一种特殊表现,即右冠状动脉和回旋支显示出100%的显著狭窄,同时左前降支近端狭窄90%-95%。值得注意的是,这种情况发生在一名患有T1DM引发的广泛并发症的患者身上。此外,它强调了及时识别韦伦综合征的存在并迅速启动适当医疗干预的至关重要性。

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