肝脏移植免疫反应中的树突状细胞。
Dendritic cells in liver transplantation immune response.
作者信息
Du Xiaodong, Li Mingqian, Huan Chen, Lv Guoyue
机构信息
Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, China.
Center of Infectious Diseases and Pathogen Biology, Institute of Virology and AIDS Research, Key Laboratory of Organ Regeneration and Transplantation of The Ministry of Education, The First Hospital of Jilin University, Changchun, China.
出版信息
Front Cell Dev Biol. 2023 Oct 13;11:1277743. doi: 10.3389/fcell.2023.1277743. eCollection 2023.
Dendritic cells (DCs) are the most powerful antigen presenting cells (APCs), they are considered one of the key regulatory factors in the liver immune system. There is currently much interest in modulating DC function to improve transplant immune response. In liver transplantation, DCs participate in both the promotion and inhibition of the alloreponse by adopting different phenotypes and function. Thus, in this review, we discussed the origin, maturation, migration and pathological effects of several DC subsets, including the conventional DC (cDC), plasmacytoid DC (pDC) and monocyte-derived DC (Mo-DC) in liver transplantation, and we summarized the roles of these DC subsets in liver transplant rejection and tolerance. In addition, we also outlined the latest progress in DC-based related treatment regimens. Overall, our discussion provides a beneficial resource for better understanding the biology of DCs and their manipulation to improve the immune adaptability of patients in transplant status.
树突状细胞（DCs）是最强大的抗原呈递细胞（APCs），它们被认为是肝脏免疫系统中的关键调节因子之一。目前，人们对调节DC功能以改善移植免疫反应非常感兴趣。在肝移植中，DCs通过采用不同的表型和功能，既参与同种异体反应的促进，也参与其抑制。因此，在本综述中，我们讨论了几种DC亚群在肝移植中的起源、成熟、迁移及病理作用，包括传统DC（cDC）、浆细胞样DC（pDC）和单核细胞衍生DC（Mo-DC），并总结了这些DC亚群在肝移植排斥和耐受中的作用。此外，我们还概述了基于DC的相关治疗方案的最新进展。总体而言，我们的讨论为更好地理解DCs的生物学特性及其调控，以提高移植状态下患者的免疫适应性提供了有益的参考。
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