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通过多种瑜伽和冥想方式进行端粒长度调节的叙述性综述:当前见解与未来方向

A Narrative Review of Telomere Length Modulation Through Diverse Yoga and Meditation Styles: Current Insights and Prospective Avenues.

作者信息

Aghajanyan Vahe, Bhupathy Supriya, Sheikh Shazia, Nausheen Fauzia

机构信息

Medical Education, California University of Science and Medicine, Colton, USA.

Education, California University of Science and Medicine, Colton, USA.

出版信息

Cureus. 2023 Sep 28;15(9):e46130. doi: 10.7759/cureus.46130. eCollection 2023 Sep.

Abstract

Mindfulness practices have demonstrated the potential to positively impact various aspects of human health associated with telomere length (TL) - a recognized marker of healthy aging and susceptibility to age-related diseases. This review seeks to conduct an in-depth comparative analysis, examining methodological variations, outcome assessments, strengths, weaknesses, and gaps across mindfulness-focused studies concerning TL and attrition rates. While emerging data tentatively suggest a positive connection between mindfulness practices and TL, a notable research gap pertains to establishing the clinically recommended dosage of yoga/meditation and mindfulness interventions to effectively influence TL. To address this gap, upcoming research should prioritize meticulous structuring, pedagogical precision, and vigilant monitoring of mindfulness interventions to yield psychological and physiological benefits across an appropriate timeframe and intensity. The amalgamation of yoga/meditation or mindfulness emerges as a promising avenue for enhancing the quality of life while counteracting the influence of telomere attrition in the spectrum of age-related diseases. The core objective of this review is to meticulously investigate the interplay between yoga/meditation and mindfulness practices and their potential impact on TL - an essential biomarker indicative of age-related health and well-being. To achieve this, our study methodically compares various methodological approaches, outcome measures, strengths, and limitations within relevant research endeavors focused on TL and attrition rates. Through this scrutiny, we highlight prevailing research gaps. Our analysis underscores the need for comprehensive research efforts aimed at establishing the optimal therapeutic regimen for yielding significant clinical effects on TL and overall health. In summation, our exploration emphasizes the urgency of further studies to unravel the most effective approaches for positively influencing TL and its implications for holistic health.

摘要

正念练习已显示出对与端粒长度(TL)相关的人类健康各个方面产生积极影响的潜力——端粒长度是公认的健康衰老和与年龄相关疾病易感性的标志物。本综述旨在进行深入的比较分析,审视有关端粒长度和损耗率的正念研究在方法学差异、结果评估、优势、劣势及差距。虽然新出现的数据初步表明正念练习与端粒长度之间存在积极联系,但一个显著的研究差距在于确定瑜伽/冥想和正念干预的临床推荐剂量,以有效影响端粒长度。为填补这一差距,未来的研究应优先精心构建、精准教学并密切监测正念干预,以便在适当的时间框架和强度内产生心理和生理益处。瑜伽/冥想或正念的融合成为提高生活质量、同时抵消端粒损耗在与年龄相关疾病范围内影响的一条有前景的途径。本综述的核心目标是细致研究瑜伽/冥想和正念练习之间的相互作用及其对端粒长度的潜在影响——端粒长度是与年龄相关的健康和幸福的重要生物标志物。为实现这一目标,我们的研究系统地比较了专注于端粒长度和损耗率的相关研究工作中的各种方法学途径、结果测量、优势和局限性。通过这种审查,我们突出了当前的研究差距。我们的分析强调了开展全面研究工作的必要性,旨在确定对端粒长度和整体健康产生显著临床效果的最佳治疗方案。总之,我们的探索强调了进一步研究以揭示积极影响端粒长度的最有效方法及其对整体健康影响的紧迫性。

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