初级卫生保健患者的白细胞端粒长度与抑郁、焦虑、压力及适应障碍
Leukocyte telomere length and depression, anxiety and stress and adjustment disorders in primary health care patients.
作者信息
Wang Xiao, Sundquist Kristina, Hedelius Anna, Palmér Karolina, Memon Ashfaque A, Sundquist Jan
机构信息
Center for Primary Health Care Research, Lund University/Region Skåne, Malmö, Sweden.
出版信息
BMC Psychiatry. 2017 Apr 24;17(1):148. doi: 10.1186/s12888-017-1308-0.
BACKGROUND
The primary aim was to examine possible differences in telomere length between primary health care patients, with depression, anxiety or stress and adjustment disorders, and healthy controls. The second aim was to examine the association between telomere length and baseline characteristics in the patients. The third aim was to examine the potential effects of the 8-week treatments (mindfulness-based group therapy or treatment as usual, i.e. mostly cognitive-based therapy) on telomere length, and to examine whether there was a difference in the potential effect on telomere length between the two groups.
METHODS
A total of 501 individuals including 181 patients (aged 20-64 years), with depression, anxiety and stress and adjustment disorders, and 320 healthy controls (aged 19-70 years) were recruited in the study. Patient data were collected from a randomized controlled trial comparing mindfulness-based group therapy with treatment as usual. We isolated genomic DNA from blood samples, collected at baseline and after the 8-week follow-up. Telomere length was measured by quantitative real-time (qRT)-PCR.
RESULTS
Telomere length was significantly shorter in the patients (mean = 0.77 ± 0.12,), compared to the controls (mean = 0.81 ± 0.14) (p = 0.006). The difference in telomere length remained significant after controlling for age and sex. Old age, male sex and being overweight were associated with shorter telomere length. There was no significant difference in telomere length between baseline and at the 8-week follow-up in any of the treatment groups and no difference between the two groups.
CONCLUSION
Our findings confirm that telomere length, as compared with healthy controls, is shortened in patients with depression, anxiety and stress and adjustment disorders. In both groups (mindfulness-based group therapy or treatment as usual), the telomere length remained unchanged after the 8-week treatment/follow-up and there was no difference between the two groups.
TRIAL REGISTRATION
(ClinicalTrials.gov ID: NCT01476371 ) Registered November 11, 2011.
背景
主要目的是研究患有抑郁症、焦虑症、压力和适应障碍的初级卫生保健患者与健康对照者之间端粒长度的可能差异。第二个目的是研究患者端粒长度与基线特征之间的关联。第三个目的是研究为期8周的治疗（正念团体治疗或常规治疗，即主要是认知行为治疗）对端粒长度的潜在影响，并研究两组对端粒长度的潜在影响是否存在差异。
方法
本研究共招募了501名个体，包括181名患有抑郁症、焦虑症、压力和适应障碍的患者（年龄20 - 64岁）以及320名健康对照者（年龄19 - 70岁）。患者数据来自一项比较正念团体治疗与常规治疗的随机对照试验。我们从基线和8周随访后采集的血样中提取基因组DNA。通过定量实时（qRT）-PCR测量端粒长度。
结果
与对照组（平均值 = 0.81 ± 0.14）相比，患者的端粒长度显著缩短（平均值 = 0.77 ± 0.12）（p = 0.006）。在控制年龄和性别后，端粒长度的差异仍然显著。老年、男性和超重与较短的端粒长度相关。任何治疗组在基线和8周随访时端粒长度均无显著差异，两组之间也无差异。
结论
我们的研究结果证实，与健康对照者相比，患有抑郁症、焦虑症、压力和适应障碍的患者端粒长度缩短。在两组（正念团体治疗组或常规治疗组）中，8周治疗/随访后端粒长度均保持不变，两组之间无差异。
试验注册
（ClinicalTrials.gov标识符：NCT01476371）于2011年11月11日注册。
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