Bajaj Pavan, Shirbhate Unnati, Dare Sneha
Department of Periodontics, Sharad Pawar Dental College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Cureus. 2023 Sep 25;15(9):e45968. doi: 10.7759/cureus.45968. eCollection 2023 Sep.
A dental implant is an alloplastic framework inserted into the bone, either straight through the alveolar bone or beneath the mucosa or periosteum, to support and hold a permanent or removable dental prosthesis. Osseointegration is a striking phenomenon in which bone directly opposes the implant surface without any interposing collagen or fibroblastic matrix. Although titanium metallic implants were the subject of "osseointegration" at first, it is now used to refer to any biomaterial that can osseointegrate. The science of tissue engineering allows for regenerating complete biological components outside the body for possible replacement treatment or therapy. It uses cells, organic or synthetic scaffold materials, and bioactive molecules. The combination of periodontal ligament (PDL) cells with implant biomaterial is known as Ligaplants. When placed in regions with significant periodontal bone defects, ligaplants can promote the development of new bone. PDL implants, inserted into the missing teeth extraction socket, facilitate surgery. To protect the PDL cell cushion, ligaplants are fitted initially loosely. However, they firmly integrate without interlocking or making direct contact with the bones. Osseointegrated implants affixed directly to the alveolar bone encircling them cannot serve the same purpose as healthy teeth because natural periodontal tissue deteriorates over time. To create a biological connection capable of performing specific physiological tasks, a tissue-engineered PDL must be constructed in conjunction with a dental implant that is well thought out.
牙种植体是一种植入骨内的异体塑料框架,可直接穿过牙槽骨,或置于黏膜或骨膜下方,以支撑和固定永久性或可摘式假牙。骨结合是一种显著现象,即骨直接与种植体表面相对,中间没有任何胶原或成纤维细胞基质。虽然钛金属种植体最初是“骨结合”的研究对象,但现在它被用于指代任何能够实现骨结合的生物材料。组织工程学能够在体外再生完整的生物组件,用于可能的替代治疗。它使用细胞、有机或合成支架材料以及生物活性分子。牙周膜(PDL)细胞与种植体生物材料的组合被称为“韧带种植体”。当放置在牙周骨缺损严重的区域时,韧带种植体可以促进新骨的生长。插入缺失牙拔牙窝的PDL种植体便于手术操作。为了保护PDL细胞垫,韧带种植体最初安装得较松。然而,它们会牢固地整合,不会与骨互锁或直接接触。直接固定在环绕它们的牙槽骨上的骨结合种植体无法起到与健康牙齿相同的作用,因为天然牙周组织会随着时间而退化。为了建立一种能够执行特定生理任务的生物连接,必须结合精心设计的牙种植体构建组织工程化的PDL。