Hagen T M, Brown L A, Jones D P
Biochem Pharmacol. 1986 Dec 15;35(24):4537-42. doi: 10.1016/0006-2952(86)90776-8.
Exogenous GSH provided rat alveolar type II cells with significant protection against injury induced by paraquat. This protection was also observed in cells treated with acivicin to inhibit GSH degradation and buthionine sulfoximine to inhibit GSH synthesis. Exogenous GSH was transported into cells by a Na+-dependent system. Addition of inhibitors of this transport system, gamma-glutamyl-glutamate and probenecid, prevented the protection against injury afforded by GSH. Thus, the results indicate that alveolar type II cells can supplement endogenous synthesis of GSH with uptake of exogenous GSH to protect against paraquat-induced injury.
外源性谷胱甘肽（GSH）为大鼠肺泡Ⅱ型细胞提供了显著的保护作用，使其免受百草枯诱导的损伤。在用阿西维辛抑制GSH降解以及用丁硫氨酸亚砜胺抑制GSH合成处理的细胞中也观察到了这种保护作用。外源性GSH通过一种钠依赖性系统转运进入细胞。添加该转运系统的抑制剂γ-谷氨酰-谷氨酸和丙磺舒可阻止GSH提供的抗损伤保护作用。因此，结果表明肺泡Ⅱ型细胞可以通过摄取外源性GSH来补充内源性GSH的合成，从而抵御百草枯诱导的损伤。
