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癫痫的神经刺激机制

Mechanisms of Neurostimulation for Epilepsy.

作者信息

Toprani Sheela, Durand Dominique M

机构信息

Neurology, Division of Epilepsy, University of California Davis, CA, USA.

Department of Biomedical Engineering, Neural Engineering Center, Case Western Reserve University, Cleveland, OH, USA.

出版信息

Epilepsy Curr. 2023 Oct 15;23(5):298-302. doi: 10.1177/15357597231191887. eCollection 2023 Sep-Oct.

DOI:10.1177/15357597231191887
PMID:37901784
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10601041/
Abstract

This review discusses the use of neurostimulation therapies for epilepsy treatment, including vagal nerve stimulation, responsive neurostimulation, and deep brain stimulation. Different therapeutic strategies and their underlying mechanisms are explored, with a focus on optimizing parameters for seizure reduction. The review also highlights the paradigm shift toward a more diverse and multimodal approach to deep brain neuromodulation.

摘要

本综述讨论了神经刺激疗法在癫痫治疗中的应用,包括迷走神经刺激、反应性神经刺激和深部脑刺激。探讨了不同的治疗策略及其潜在机制,重点是优化减少癫痫发作的参数。该综述还强调了深部脑神经调节向更加多样化和多模式方法的范式转变。

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Mechanisms of Neurostimulation for Epilepsy.癫痫的神经刺激机制
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2
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本文引用的文献

1
Quantifying seizure termination patterns reveals limited pathways to seizure end.量化癫痫发作终止模式揭示了癫痫发作结束的有限途径。
Neurobiol Dis. 2022 Apr;165:105645. doi: 10.1016/j.nbd.2022.105645. Epub 2022 Jan 29.
2
Epileptic Seizure Cycles: Six Common Clinical Misconceptions.癫痫发作周期:六个常见的临床误解
Front Neurol. 2021 Aug 4;12:720328. doi: 10.3389/fneur.2021.720328. eCollection 2021.
3
Low-frequency electrical stimulation reduces cortical excitability in the human brain.低频电刺激可降低人脑皮质兴奋性。
Neuroimage Clin. 2021;31:102778. doi: 10.1016/j.nicl.2021.102778. Epub 2021 Jul 28.
4
Modelling and prediction of the dynamic responses of large-scale brain networks during direct electrical stimulation.直接电刺激下大规模脑网络动态响应的建模与预测。
Nat Biomed Eng. 2021 Apr;5(4):324-345. doi: 10.1038/s41551-020-00666-w. Epub 2021 Feb 1.
5
A model for focal seizure onset, propagation, evolution, and progression.局灶性癫痫发作的起始、传播、演变和进展模型。
Elife. 2020 Mar 23;9:e50927. doi: 10.7554/eLife.50927.
6
Comparison of fiber tract low frequency stimulation to focal and ANT stimulation in an acute rat model of focal cortical seizures.纤维束低频刺激与焦点和ANT 刺激在急性局灶性皮质癫痫大鼠模型中的比较。
Brain Stimul. 2020 Mar-Apr;13(2):499-506. doi: 10.1016/j.brs.2019.12.026. Epub 2019 Dec 28.
7
Cellular, molecular, and clinical mechanisms of action of deep brain stimulation-a systematic review on established indications and outlook on future developments.深部脑刺激的作用机制:细胞、分子和临床——对既定适应证的系统评价及未来发展展望。
EMBO Mol Med. 2019 Apr;11(4). doi: 10.15252/emmm.201809575.
8
Brain-responsive neurostimulation for epilepsy (RNS System).用于癫痫治疗的脑响应神经刺激(RNS系统)。
Epilepsy Res. 2019 Jul;153:68-70. doi: 10.1016/j.eplepsyres.2019.02.003. Epub 2019 Feb 20.
9
Transient seizure onset network for localization of epileptogenic zone: effective connectivity and graph theory-based analyses of ECoG data in temporal lobe epilepsy.短暂性发作起始网络用于致痫灶定位:基于 ECoG 数据的有效连通性和图论分析在颞叶癫痫中的应用。
J Neurol. 2019 Apr;266(4):844-859. doi: 10.1007/s00415-019-09204-4. Epub 2019 Jan 25.
10
Corpus callosum low-frequency stimulation suppresses seizures in an acute rat model of focal cortical seizures.胼胝体低频刺激抑制局灶性皮质癫痫急性大鼠模型的发作。
Epilepsia. 2018 Dec;59(12):2219-2230. doi: 10.1111/epi.14595. Epub 2018 Nov 13.