Department of Critical Care Medicine, The People's Hospital of Yuhuan, Taizhou, Zhejiang 317600, China.
Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325001, China.
J Mater Chem B. 2023 Nov 22;11(45):10778-10792. doi: 10.1039/d3tb02220j.
Bacterial sepsis is a life-threatening condition caused by bacteria entering the bloodstream and triggering an immune response, underscoring the importance of early recognition and prompt treatment. Nanomedicine holds promise for addressing sepsis through improved diagnostics, nanoparticle biosensors for detection and imaging, enhanced antibiotic delivery, combating resistance, and immune modulation. However, challenges remain in ensuring safety, regulatory compliance, scalability, and cost-effectiveness before clinical implementation. Further research is needed to optimize design, efficacy, safety, and regulatory strategies for effective utilization of nanomedicines in bacterial sepsis diagnosis and treatment. This review highlights the significant potential of nanomedicines, including improved drug delivery, enhanced diagnostics, and immunomodulation for bacterial sepsis. It also emphasizes the need for further research to optimize design, efficacy, safety profiles, and address regulatory challenges to facilitate clinical translation.
细菌败血症是一种危及生命的疾病，由细菌进入血液并引发免疫反应引起，这突显了早期识别和及时治疗的重要性。纳米医学通过改进的诊断方法、用于检测和成像的纳米粒子生物传感器、增强的抗生素传递、对抗耐药性和免疫调节，为治疗败血症提供了希望。然而，在临床实施之前，仍然存在确保安全性、法规遵从性、可扩展性和成本效益的挑战。需要进一步的研究来优化设计、功效、安全性和监管策略，以有效利用纳米医学进行细菌败血症的诊断和治疗。这篇综述强调了纳米医学的巨大潜力，包括改进的药物传递、增强的诊断和免疫调节治疗细菌败血症。它还强调了需要进一步研究来优化设计、疗效、安全性概况，并解决监管挑战，以促进临床转化。
